Effect of Weihe Ⅱ Powder on Pathomorphological Changes and Anti-oxidative Activities in Rats with Chronic Atrophic Gastritis

WANG Yan; MA Chun-jie; SONG Mei-dan; WANG Bin; KANG Yong; DONG Ping

doi:10.13422/j.cnki.syfjx.2010.12.038

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Effect of Weihe Ⅱ Powder on Pathomorphological Changes and Anti-oxidative Activities in Rats with Chronic Atrophic Gastritis

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- Effect of Weihe Ⅱ Powder on Pathomorphological Changes and Anti-oxidative Activities in Rats with Chronic Atrophic Gastritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 12, Pages: 129-131(2010)
- 作者机构：
  
  内蒙古医学院中医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.12.038
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]王艳,麻春杰,宋美丹,王滨,康永,董平.胃和冲剂Ⅱ号对慢性萎缩性胃炎大鼠病理形态学及抗氧化酶活性的影响[J].中国实验方剂学杂志,2010,16(12):129-131.

WANG Yan, MA Chun-jie, SONG Mei-dan, et al. Effect of Weihe Ⅱ Powder on Pathomorphological Changes and Anti-oxidative Activities in Rats with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 129-131.
[1]王艳,麻春杰,宋美丹,王滨,康永,董平.胃和冲剂Ⅱ号对慢性萎缩性胃炎大鼠病理形态学及抗氧化酶活性的影响[J].中国实验方剂学杂志,2010,16(12):129-131. DOI： 10.13422/j.cnki.syfjx.2010.12.038.

WANG Yan, MA Chun-jie, SONG Mei-dan, et al. Effect of Weihe Ⅱ Powder on Pathomorphological Changes and Anti-oxidative Activities in Rats with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 129-131. DOI： 10.13422/j.cnki.syfjx.2010.12.038.

摘要

目的:研究胃和冲剂Ⅱ号对大鼠慢性萎缩性胃炎（CAG）的治疗作用

并探讨其作用机制。方法:采用综合法建立CAG大鼠模型

造模成功后给予胃和冲剂Ⅱ号治疗

观察此方对CAG大鼠胃黏膜组织形态及血清抗氧化酶活性的影响。结果:胃和冲剂Ⅱ号明显改善CAG大鼠病损程度

增加CAG大鼠胃窦黏膜腺体层厚度（P<0.01）、降低胃窦黏膜肌层厚度（P<0.05）

使腺体萎缩得到恢复

炎症反应减轻;可提高CAG大鼠血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性、降低MDA含量（P<0.05）。结论:胃和冲剂Ⅱ号能改善和逆转试验性CAG大鼠胃黏膜的病理变化

对CAG具有良好的治疗作用。其机制可能与增强抗氧化酶活性、减轻自由基损伤有关。

Abstract

Objective: To study the effect and the mechanism of Weihe Ⅱ Powder on rats with chronic atrophic gastritis（CAG）.Method: Chronic atrophic gastritis of rat was established through a synthesized method.The rats were treated with Weihe Ⅱ Powder after the model was made successfully.The influences of the powder on morphology of gastric mucosa and anti-oxidative enzyme activities in serum of the rats with CAG were investigated.Result: Weihe Ⅱ Powder could reduce the injuries in CAG rats

increase the thickness of mucosa glandular（P < 0.01） to restore the gastric mucosa

reduce inflammatory reactions

enhance activities of SOD and GSH-Px

decrease content of MDA（P < 0.05）.Conclusion: Weihe Ⅱ Powder could improve pathomorphological changes in CAG rats.It might be related with enhancement of anti-oxidative enzyme activities to avoid injuries induced by free radicals.

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Related Institution

Functional Experimental Centre of Yanbian University Medical Department,Yanji

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