Protective Effect of Qifu Yin on Neuronal Apoptosis in Rats with Alzheimer’s Disease Induced by Beta-amyloid Hippocampus

XING Gui-hua; LIN Chun-rong; ZHANG Xiao-jie; NIU Ying-cai; LI Xue-yan

doi:10.13422/j.cnki.syfjx.2010.12.041

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Protective Effect of Qifu Yin on Neuronal Apoptosis in Rats with Alzheimer’s Disease Induced by Beta-amyloid Hippocampus

更新时间：2024-09-23

- Protective Effect of Qifu Yin on Neuronal Apoptosis in Rats with Alzheimer’s Disease Induced by Beta-amyloid Hippocampus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 12, Pages: 138-141(2010)
- 作者机构：
  
  黑龙江省齐齐哈尔医学院中心试验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.12.041
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]兴桂华,林春荣,张晓杰,牛英才,李雪岩.七福饮对Aβ_(1-42)诱导老年性痴呆模型大鼠海马神经细胞凋亡的保护作用[J].中国实验方剂学杂志,2010,16(12):138-141.

XING Gui-hua, LIN Chun-rong, ZHANG Xiao-jie, et al. Protective Effect of Qifu Yin on Neuronal Apoptosis in Rats with Alzheimer’s Disease Induced by Beta-amyloid Hippocampus[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 138-141.
[1]兴桂华,林春荣,张晓杰,牛英才,李雪岩.七福饮对Aβ_(1-42)诱导老年性痴呆模型大鼠海马神经细胞凋亡的保护作用[J].中国实验方剂学杂志,2010,16(12):138-141. DOI： 10.13422/j.cnki.syfjx.2010.12.041.

XING Gui-hua, LIN Chun-rong, ZHANG Xiao-jie, et al. Protective Effect of Qifu Yin on Neuronal Apoptosis in Rats with Alzheimer’s Disease Induced by Beta-amyloid Hippocampus[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 138-141. DOI： 10.13422/j.cnki.syfjx.2010.12.041.

摘要

目的:探讨七福饮对海马注射β-淀粉样蛋白（Aβ1-42）的大鼠海马神经细胞凋亡的保护作用及机制。方法:84只SD健康大鼠随机分为空白对照组、假手术组、模型组、西药组、七福饮低剂量、七福饮中剂量和七福饮高剂量组

凝聚态Aβ1-42大鼠海马定向注射诱导老年性痴呆（Alzheime’s disease

AD）动物模型

采用免疫印迹法检测大鼠脑组织Bcl-2和Bax蛋白的表达

透射电镜观察海马组织超微结构的变化。结果:与假手术组比较

模型组Bax蛋白表达相对值显著升高

而Bcl-2相对值显著降低（P<0.05）;与模型组比较

西药组、七福饮低、中、高各剂量组Bax蛋白表达相对值显著降低（P<0.05）

而七福饮低、中、高各剂量组Bcl-2蛋白表达相对值显著升高（P<0.05）。电子显微镜观察结果表明

模型组大鼠海马变性

七福饮能改善大鼠海马神经元病理改变。结论:七福饮可通过调节海马组织Bax和Bcl-2基因的表达水平、抑制神经细胞凋亡的发生

而对AD大鼠损伤的神经细胞起到保护作用。

Abstract

Objective:To observe the protective effect of Qifu Yin on the apoptosis in hippocampal neurons in Alzheimer’s disease（AD） rats induced by amyloid-β1-42 injection.Method: Eighty-four SD rats were equally randomly divided into blank control group

sham controls group

model control group

donepezil control group and Qifu yin groups（2.15

4.3

8.6 mg.kg-1）.The AD model was established by amyloid-β1-42 injection into the bilateral hippocampus.Expression of Bax and Bcl-2 protein in rat brain was estimated by western blotting method.Change of hippocampus is observed by electron microscope.Result:The expression of protein Bax was up-regulated in model group compared with the sham group and Bcl-2 was down-regulated.In Qifu Yin group

the Bax expression was down-regulated and Bcl-2 up-regulated compared with the model group（P < 0.05）.Qifu Yin can alleviate the damage of hippocampus neurons.Conclusion:Amyloid-β1-42 injection into the bilateral hippocampus can up-regulate expression of protein Bax and down-regulate expression of Bcl-2 in brain tissue.Qifu Yin inhibits apoptosis through regulating the expression of Bcl-2 and Bax protein in hippocampal.may provide some protective effects on cerebral neurons damage of AD model in rats.

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