Shange Lipid-lowering Dispersible Tablets of Puerarin in Rats in vivo Pharmacokinetic Study

ZHANG Hai-yan; CHENG Lan; YUAN Zi-min; LI Xue-tao; WANG Jing

doi:10.13422/j.cnki.syfjx.2010.12.049

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Shange Lipid-lowering Dispersible Tablets of Puerarin in Rats in vivo Pharmacokinetic Study

更新时间：2024-09-23

- Shange Lipid-lowering Dispersible Tablets of Puerarin in Rats in vivo Pharmacokinetic Study
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 12, Pages: 169-171(2010)
- 作者机构：
  
  辽宁中医药大学药学院药剂教研室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.12.049
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]张海燕,程岚,袁子民,李学涛,王静.山葛降脂分散片中葛根素在大鼠体内的药代动力学研究[J].中国实验方剂学杂志,2010,16(12):169-171.

ZHANG Hai-yan, CHENG Lan, YUAN Zi-min, et al. Shange Lipid-lowering Dispersible Tablets of Puerarin in Rats in vivo Pharmacokinetic Study[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 169-171.
[1]张海燕,程岚,袁子民,李学涛,王静.山葛降脂分散片中葛根素在大鼠体内的药代动力学研究[J].中国实验方剂学杂志,2010,16(12):169-171. DOI： 10.13422/j.cnki.syfjx.2010.12.049.

ZHANG Hai-yan, CHENG Lan, YUAN Zi-min, et al. Shange Lipid-lowering Dispersible Tablets of Puerarin in Rats in vivo Pharmacokinetic Study[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 169-171. DOI： 10.13422/j.cnki.syfjx.2010.12.049.

摘要

目的:山葛降脂分散片和葛根分散片中葛根素在大鼠体内药代动力学的对比研究。方法:以香草醛为内标物

利用HPLC测定大鼠血浆中葛根素的含量。结果:山葛降脂分散片的主要药动学参数:Tmax（3.000±0.371）h

Cmax（3.159±0.415）mg·L-1

AUC0→∞（19.593±3.168）mg·L-1·h-1

MRT0→∞（11.370±2.358）h;葛根分散片的主要药动学参数:Tmax（4.000±0.313）h

Cmax（2.784±0.398）mg·L-1

AUC0→∞（17.605±3.993）mg·L-1·h-1

MRT0→∞（8.678±1.625）h。结论:山楂叶和葛根提取物合用能使葛根素的吸收加快

浓度增大

消除减慢。房室模型拟合分析为二房室模型。

Abstract

Objective: To comparative research puerarin of Shange lipid-lowering dispersible tablets and Gegen dispersible tablets in rats in vivo pharmacokinetics.Method: With vanillin as internal standard

HPLC was used to determine the contents of puerarin in rat plasma.Result: The main pharmacokinetic parameters of Shange lipid-lowering dispersible tablets: Tmax（3.000 ± 0.371） h

Cmax（3.159 ± 0.415） mg·L-1

AUC0→∞（19.593 ± 3.168） mg·L-1.h-1

MRT0→∞（11.370 ± 2.358） h;The main pharmacokinetic parameters of Gegen dispersible tablets: Tmax（4.000 ± 0.313） h

Cmax（2.784 ± 0.398） mg·L-1

AUC0→∞（17.605 ± 3.993） mg·L-1·h-1

MRT0→∞（8.678 ± 1.625） h.Conclusions:The extract of Hawthorn leaves and Pueraria combination can speed up the absorption of puerarin

the concentration increases and elimination of slow down.By the analysis of compartment model

it is two compartment model.

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Related Author

ZHANG Hai-yan

CHENG Lan

YUAN Zi-min

LI Xue-tao

Wang Jing

WANG Li2

XING Dong-ming1

SUN Hong2

Related Institution

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Tianjin University of TCM

First Teaching Hospital of Tianjin University of TCM

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