Nitric Oxide（NO）is a vital signal messenger intracelluarly and intercellularly and generated by nitric oxide synthase including endothelial nitric oxide synthase（eNOS）

inducible nitric oxide synthase（iNOS） and neuropathic nitric oxide synthase（nNOS）.In various physiological processes

eNOS and nNOS in the organization continue the low level expression to maintenance normal physiology function.When eNOS activity declines to reduce NO in the pathology situation

Chinese medicinal herbs regulate eNOS activity through protein phosphorylation to restore the NO physiology concentration and improve NO bioavailability through antioxidation effects.In the physiological situation iNOS does not express

iNOS is activated and generate massive NO that damage organization and aggravate inflammation advance under inflammation condition.Chinese herbs down regulate iNOS through nuclear factor-κB and p38 mitogen-activated protein kinase to reduce NO and treat inflammation.Many blood-activating and stasis-removing Chinese medicines regulate inducible nitric oxide synthase with antiinflammatory effect

to provide experimental base to treat inflammation.