Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine

LI Lei1; CHEN Jun1; CAI Bao-chang1; QI Yan1

doi:10.13422/j.cnki.syfjx.2010.14.019

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Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine

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- Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 14, Pages: 1-3(2010)
- 作者机构：
  
  1. 南京中医药大学药学院
  2. 江苏省中药炮制重点实验室
  3. 国家教育部中药炮制规范化及标准化工程研究中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.14.019
  CLC： R285
- Published：2010
- 稿件说明：
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[1]李磊,陈军,蔡宝昌,祁艳.pH对马钱子碱经皮吸收性质与抗炎作用的影响[J].中国实验方剂学杂志,2010,16(14):1-3+8.

LI Lei1, CHEN Jun1, CAI Bao-chang1, et al. Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 1-3.
[1]李磊,陈军,蔡宝昌,祁艳.pH对马钱子碱经皮吸收性质与抗炎作用的影响[J].中国实验方剂学杂志,2010,16(14):1-3+8. DOI： 10.13422/j.cnki.syfjx.2010.14.019.

LI Lei1, CHEN Jun1, CAI Bao-chang1, et al. Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 1-3. DOI： 10.13422/j.cnki.syfjx.2010.14.019.

摘要

目的:考察不同pH对马钱子碱油水分配系数、体外经皮吸收性质与抗炎作用的影响。方法:测定马钱子碱在pH5

7.4

9的磷酸盐缓冲溶液（PBS）中的油水分配系数和体外经皮吸收速率;用二甲苯致小鼠耳壳肿胀

分别测定马钱子碱在pH 5

7.4

9的PBS中对肿胀的抑制作用。结果:与pH 5相比

马钱子碱在pH 9的PBS中的油水分配系数和经皮吸收速率显著提高

分别为239.5倍和3.15倍

且对小鼠耳肿胀的抑制作用明显增强。结论:增大pH可提高马钱子碱的油水分配系数及体外透皮性质

促进马钱子碱的经皮吸收

并且有利于抗炎作用的发挥。

Abstract

Objective:To study the influence of differenet pH on the oil-water partition co-efficient

trans- dermal absorption characteristics and the anti-inflammation effect of brucine solution. Method:The oil-water parti- tion co-efficients and the permeation rates of brucine in pH 5

7. 4 and 9 phosphate buffer solution （ PBS） were measured; The effects of brucine in pH5

7. 4 and pH 9 on the inflammatory edema of ear induced by xylol in mice were also determined. Result:The oil-water partition coefficient and permeation rate of brucine in pH 9 were （22. 17 ± 0. 4） and （2. 84 ± 0. 10）μg·cm -2·h -1

which was almost 239. 5 times and 3. 15 times more than the cor- responding data obtained under pH 5 PBS. The effect of inhibiting the inflammatory edema in the ear of mice in- duced by xylol was also markly increased under pH 9. Conclusion:The oil-water partition coefficient and transder- mal absorption characteristics of brucine can be improved by increasing pH. which also markly promotes the anti-in- flammatory activities of brucine.

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Related Author

LI Lei

Chen Jun

CAI Bao-chang

QI Yan

LI Pengcheng

CHEN Tianyang

FANG Rong

ZHANG Anna

Related Institution

The NATCM Third Grade Laboratory of TCM Preparations，Key Laboratory of Liver and Kidney Diseases （Ministry of Education）， Shanghai Key Laboratory of Traditional Chinese Clinical Medicine， Shuguang Hospital Affiliated to Shanghai University of TCM

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine （TCM）

Institute of Chinese Materia Medica， Shanghai University of TCM

College of Pharmaceutical Sciences， Zhejiang Chinese Medical University

Biosafety Laboratory，Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences

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