YU Hai-ling, LI Ying-jun, ZHANG Xiao-jie, et al. Protective Effect of Ligularia fischeri Ledeb Turz. against Acute Alcohol Intoxication in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 147-149.
YU Hai-ling, LI Ying-jun, ZHANG Xiao-jie, et al. Protective Effect of Ligularia fischeri Ledeb Turz. against Acute Alcohol Intoxication in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 147-149. DOI: 10.13422/j.cnki.syfjx.2010.14.060.
Protective Effect of Ligularia fischeri Ledeb Turz. against Acute Alcohol Intoxication in Mice
Objective:To investigate the protective effect of the ethanol extract of Ligularia fischeri Ledeb Turcz.in mice on acute alcohol intoxication.Method:We recorded the duration from disappearance of righting reflex(drunk) to restore(hangover) in mice
after given a gavage of 56 degrees liquor.In addition
alcohol-induced liver injury model of mice was established by acute gavage of 52 degrees liquor
and serum alanine aminotransferase(ALT) activity
malondialdehyde(MDA)
triglyceride(TG) content were tested.Activity of glutamic-pyruvic transaminase(ALT)
glutathione peroxidase(GSH-Px)
malondialdehyde(MDA)
triglyceride(TG) in liver tissue was also determined.Result:The ethanol extract of L.fischeri significantly prolonged the incubation period of righting reflex disappeared(drunk)(P < 0.05)
reduced hangover time(P < 0.05);significantly depressed TG and ALT levels(P < 0.05) in serum and liver tissue;and significantly increased GSH-Px activity(P < 0.01) in liver tissue.Conclusion:L.fischeri may have a protective effect on acute alcohol intoxication in mice.