Establishment of Method for Content Determination of Chlorogenic Acid in Maxin Oral Liquid

WANG Dian-rong1; CHEN Hong-xi1; SHANG Qiang2

doi:10.13422/j.cnki.syfjx.2010.15.026

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Establishment of Method for Content Determination of Chlorogenic Acid in Maxin Oral Liquid

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- Establishment of Method for Content Determination of Chlorogenic Acid in Maxin Oral Liquid
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 15, Pages: 56-57(2010)
- 作者机构：
  
  1. 连云港市第一人民医院
  2. 江苏康缘药业股份有限公司
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.15.026
  CLC： R286.0
- Published：2010
- 稿件说明：
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[1]王佃荣,陈洪喜,尚强.麻杏口服液中绿原酸含量测定方法的建立[J].中国实验方剂学杂志,2010,16(15):56-57.

WANG Dian-rong1, CHEN Hong-xi1, SHANG Qiang2. Establishment of Method for Content Determination of Chlorogenic Acid in Maxin Oral Liquid[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 56-57.
[1]王佃荣,陈洪喜,尚强.麻杏口服液中绿原酸含量测定方法的建立[J].中国实验方剂学杂志,2010,16(15):56-57. DOI： 10.13422/j.cnki.syfjx.2010.15.026.

WANG Dian-rong1, CHEN Hong-xi1, SHANG Qiang2. Establishment of Method for Content Determination of Chlorogenic Acid in Maxin Oral Liquid[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 56-57. DOI： 10.13422/j.cnki.syfjx.2010.15.026.

摘要

目的:建立麻杏口服液中绿原酸的含量测定方法。方法:采用高效液相色谱法

色谱柱为Kromasil 100-5 C18（4.6mm×250 mm

5μm）

流动相为乙腈-0.1%磷酸（10∶90）

流速为1 mL·min-1

柱温为30℃

检测波长327 nm;结果:绿原酸在15.84～95.04 mg·L-1线性关系良好

标准曲线方程为Y=27.606X+27.927

r=0.999 5;结论:该方法稳定可行

结果准确

可用于麻杏口服液的质量控制。

Abstract

Objective: To set up the method for content determination of chlorogenic acid of Maxin oral.Method: HPLC was adopted performing on a kromasil C18 column（4.6 mm × 250 mm

5 μm） with acetonitrile-0.1%（w） phosphoric acid（10∶ 90） as the mobile phase at a flow rate of 1.0 mL.min-1.The detective wave length was set at 327 nm and the column temperature was at 30℃.Result:Chlorogenic acid was linear in the range of 15.84-95.04 mg·L-1.The standard curve equation was Y = 27.606 X + 27.927

r = 0.999 5.Conclusion: The method set up was stable

feasible and accurate

and it can be used to control the quality of Maxin oral.

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Related Author

WANG Dian-rong

CHEN Hong-xi

SHANG Qiang

WU Ting

ZHANG Jun

ZHOU Ling

JU Wen-zheng

TAN Heng-shan

Related Institution

Henan Engineering Research Center for Quality Control and Evaluation of Traditional Chinese Medicine（TCM），School of Pharmacy，Henan University of Chinese Medicine

Luohe Medical College

Third Affiliated Hospital of Henan University of Chinese Medicine

Tianjin University of Traditional Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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