Effects of Fuzheng Huayu Decoction on Marrow Cells Migrating into Liver in Bone Marrow Transplanted Mice Fibrosis Liver

YE Ting-jie1; YAN Xiao-feng1; JIA Dong-wei1; LIU Hui-yang1; HU Xu-dong1; LI Hua1; LI Bo-qin2; CHEN Yong-liang2; WANG Xiao-ling1

doi:10.13422/j.cnki.syfjx.2010.15.038

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Effects of Fuzheng Huayu Decoction on Marrow Cells Migrating into Liver in Bone Marrow Transplanted Mice Fibrosis Liver

更新时间：2024-09-23

- Effects of Fuzheng Huayu Decoction on Marrow Cells Migrating into Liver in Bone Marrow Transplanted Mice Fibrosis Liver
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 15, Pages: 90-94(2010)
- 作者机构：
  
  1. 上海中医药大学生物学教研室
  2. 上海中医药大学教学实验中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.15.038
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]叶(目亭)杰,闫晓风,贾冬威,刘会洋,胡旭东,李华,李伯勤,陈永亮,王晓玲.扶正化瘀方对骨髓移植肝纤维化小鼠骨髓细胞肝脏迁移的影响[J].中国实验方剂学杂志,2010,16(15):90-94.

YE Ting-jie1, YAN Xiao-feng1, JIA Dong-wei1, et al. Effects of Fuzheng Huayu Decoction on Marrow Cells Migrating into Liver in Bone Marrow Transplanted Mice Fibrosis Liver[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 90-94.
[1]叶(目亭)杰,闫晓风,贾冬威,刘会洋,胡旭东,李华,李伯勤,陈永亮,王晓玲.扶正化瘀方对骨髓移植肝纤维化小鼠骨髓细胞肝脏迁移的影响[J].中国实验方剂学杂志,2010,16(15):90-94. DOI： 10.13422/j.cnki.syfjx.2010.15.038.

YE Ting-jie1, YAN Xiao-feng1, JIA Dong-wei1, et al. Effects of Fuzheng Huayu Decoction on Marrow Cells Migrating into Liver in Bone Marrow Transplanted Mice Fibrosis Liver[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 90-94. DOI： 10.13422/j.cnki.syfjx.2010.15.038.

摘要

目的:探讨扶正化瘀方（FZHY）对肝纤维化小鼠骨髓细胞肝脏归巢的作用。方法:BABL/C雌性受鼠性别交叉法骨髓移植模型基础上

四氯化碳（CCl4）诱导肝纤维化模型;成模后

治疗组以FZHY方4.6 g.kg-1.d-1 ig 4周。PCR

病理及肝功能检测成模情况;通过FISH法标记Y染色体

观察雌性受鼠肝脏内骨髓源性细胞含量;Western blot法检测雌性受鼠肝组织基质细胞衍生因子-1（SDF-1）蛋白相对表达量。结果:与模型组比较

FZHY组小鼠

肝组织损伤明显减轻。FISH法标记Y染色体观察显示

FZHY组小鼠较模型组肝内骨髓源性细胞减少（P<0.05）。Western blot结果

FZHY组小鼠较模型组肝脏SDF-1蛋白相对表达量明显减少（P<0.01）。结论:在肝脏损伤时

FZHY可能通过抑制肝内SDF-1蛋白的表达来阻止骨髓源性细胞迁移入肝

从而一定程度上抑制骨髓源性细胞入肝后促进肝纤维化。

Abstract

Objective: The discussion straightened up the effects of the Fuzheng Huayu（FZHY） decoction on the marrow cells migrating into liver in mice fibrosis liver.Method: Based on the model of the transposition bone marrow between female and male BABL /C mice

we duplicated the CCl4 liver fibrosis mice model

and then the mice in FZHY group were administered with FZHY decoction ig for 4 weeks.Did PCR

liver function and pathology examination to view the model.

marked the Y through the FISH to observe the number of the cells from the male mice bone marrow in female mice livers

tested the chemokine SDF-1 relative expression in female mice livers by Western blot.Result: The damage of mice liver relieved obviously in FZHY decoction group compared the model group.The observation of Y chromosome dyed indicated

the number of the cells from the male mice bone marrow reduced in the FZHY decoction group compared the model group liver（P < 0.05）.The chemokine SDF-1 relative expression reduced in the FZHY decoction group compared the model group liver（P < 0.01）.Conclusion: When the liver is damaged

the FZHY decoction may be able to depress the chemokine SDF-1 expression to prevent the marrow cells to migrate into the liver

and thus in certain degree controls the marrow cell promoting the liver fibrosis.

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Related Author

YE Ting-jie

YAN Xiao-feng

JIA Dong-wei

LIU Hui-yang

HU Xu-dong

LI Hua

LI Bo-qin

CHEN Yong-liang

Related Institution

Henan General Hospital

The First Clinical Medical College of Henan University of Chinese Medicine

The First Affiliated Hospital of Henan University of Chinese Medicine

The Healthcare Center for Shishan Street of Suzhou New District

The First Affiliated Hospital of Anhui University of Chinese Medicine

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