Effect of Qianliean on Basic Fibroblast Growth Factorlevelsin in Rats Model of Benign Prostatic Hyperplasia

SUN Zi-xue1; CHEN Jian-she1; WANG De-jun2; WANG Zu-long1

doi:10.13422/j.cnki.syfjx.2010.15.041

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Effect of Qianliean on Basic Fibroblast Growth Factorlevelsin in Rats Model of Benign Prostatic Hyperplasia

更新时间：2024-09-23

- Effect of Qianliean on Basic Fibroblast Growth Factorlevelsin in Rats Model of Benign Prostatic Hyperplasia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 15, Pages: 101-104(2010)
- 作者机构：
  
  1. 河南省中医院
  2. 郑州大学第四附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.15.041
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]孙自学,陈建设,王德军,王祖龙.前列安对良性前列腺增生症大鼠模型前列腺组织碱性成纤维生长因子的影响[J].中国实验方剂学杂志,2010,16(15):101-104.

SUN Zi-xue1, CHEN Jian-she1, WANG De-jun2, et al. Effect of Qianliean on Basic Fibroblast Growth Factorlevelsin in Rats Model of Benign Prostatic Hyperplasia[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 101-104.
[1]孙自学,陈建设,王德军,王祖龙.前列安对良性前列腺增生症大鼠模型前列腺组织碱性成纤维生长因子的影响[J].中国实验方剂学杂志,2010,16(15):101-104. DOI： 10.13422/j.cnki.syfjx.2010.15.041.

SUN Zi-xue1, CHEN Jian-she1, WANG De-jun2, et al. Effect of Qianliean on Basic Fibroblast Growth Factorlevelsin in Rats Model of Benign Prostatic Hyperplasia[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 101-104. DOI： 10.13422/j.cnki.syfjx.2010.15.041.

摘要

目的:探讨前列安治疗前列腺增生症的作用机制。方法:采用大鼠去势后注射丙酸睾酮致前列腺增生法造模。分5组

即正常组、模型组、前列安低剂量0.1 g.kg-1组、前列安高剂量0.2 g.kg-1组、癃闭舒0.2 g.kg-1组

ig给药30 d后处死。摘取大鼠前列腺并用电光分析天平称重

获取前列腺指数

同时制作光镜和免疫组化标本

对每张免疫组化片进行显微定性分析并观察光镜下前列腺细胞形态变化。结果:3个治疗组大鼠前列腺重、前列腺指数及碱性成纤维生长因子（bFGF）表达水平均明显低于模型组

其中尤以前列安高剂量组最为明显。模型组大鼠前列腺组织见明显的病理性改变

前列安低剂量组大鼠前列腺组织的病理性改变较模型组减轻

高剂量组和癃闭舒组大鼠前列腺组织的病理改善最为明显。结论:前列安可降低大鼠前列腺湿重

修复增生的病理损伤

其作用机制可能与前列安抑制前列腺组织中bFGF释放有关。

Abstract

Objective:To investigate the effect of Qianliean on the treatment of benign prostatic hyperplasia and the related mechanism.Method:Rat model of benign prostatic hyperplasia was established by castration followed by injection of testosterone.The rats were randomly divided into 5 groups:the normal group

the model group

the Qianliean high-dose group

the Qianliean low-dose group

Longbishu group.The rats were treated accordingly and sacrificed after 30 d.The prostates were sampled and weighed

and the prostate index was calculated.Light microscopic and immunohistochemical specimens were prepared and investigated.Result:Prostatic weight

prostatic index and basic fibroblast growth factorlevelsin（bFGF） expression levels in three treatment groups were significantly lower than that of the model group

in particular for the Qianliean of high-dose group.Model group showed marked pathological changes in prostate tissue

Qianliean low-dose group showed alleviated pathological changes in prostate tissue compared with the model group

high-dose group and Longbishu group rats prostate tissue showed obvious improvement in pathological changes.Conclusion: Qianliean can decrease prostate wet weight in rat and alleviate pathological damage in prostate.The mechanism may be related to the inhibition of prostate tissue bFGF release.

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Related Author

WANG Zu-long

WANG De-jun

CHEN Jian-she

SUN Zi-xue

Sheng LIN

Hai-song LI

Bin WANG

Yong YANG

Related Institution

Xiyuan Hospital， China Academy of Chinese Medical Sciences

Dongzhimen Hospital， Beijing University of Chinese Medicine

State Key Laboratory of Critical Technology in Innovative Chinese Medicine

Dongfang Hospital， Beijing University of Chinese Medicine

Fangshan Hospital， Beijing University of Chinese Medicine

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