Objective: To observe the protective effect of terpenoids from Liuyueqing（TLYQ） on immunological hepatic injury in mice.Method:Seventy-two mice were randomly divided into normal group

model group

Zadaxi positive control（4.2 × 10-3 g.kg-1·d-1） group and low

medium

high-dose TLYQ-treated group（0.5

1

2 g·kg-1.d-1）.On the first day

except the blank group

other groups were injected BCG from tail vein.The next day the mice in normal and model groups were administered with nothing

while those mice in other groups were respectively administered with different medicine.By the end of the 10 th day

model

Zadaxi and three TLYQ-treated groups were injected LPS from tail vein.10 h later the mice were weighed

blood was collected from eyeball

then all of groups were sacrificed

livers were taken out.ALT and AST in serum

percentage of CD3 +

CD4 +

CD8 + and CD4 + /CD8 + of every group were determined.Liver tissue damage with HE staining was observed by light microscope.Result:Compared with model group

high

medium-dose TLYQ could significantly increase percentage of CD3 +

CD4 + cell and CD4 + /CD8 +

decrease the ratio of CD8 + and the activity of AST

ALT.And TLYQ also could reduce the balloon degeneration

punctate

patchy necrosis and inflammatory cell infiltration.Conclusion:TLYQ has a protective effect on immunological liver injury in mice.