FENG Yun-xia1, SHI Zhao-hong1, ZHANG Jie-mei1, et al. Influence of Tiaozhong Granule on Brain-gut Peptide and Nitricoxide Synthase of Rats with Mixed Reflux Esophagitis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 154-157.
FENG Yun-xia1, SHI Zhao-hong1, ZHANG Jie-mei1, et al. Influence of Tiaozhong Granule on Brain-gut Peptide and Nitricoxide Synthase of Rats with Mixed Reflux Esophagitis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 154-157. DOI: 10.13422/j.cnki.syfjx.2010.15.056.
Influence of Tiaozhong Granule on Brain-gut Peptide and Nitricoxide Synthase of Rats with Mixed Reflux Esophagitis
Objective: To study the influence of the Tiaozhong Granule on the vasoactive intestinal peptide(VIP)
substance P(SP)and nitricoxide synthase(NOS) of rats with mixed reflux esophagitis.Method: The rats were randomly divided into five groups:the model group
the normal group
the Tiaozhong granule Group
the Banxia Xiexin Tang group and cisapride group.Then anastomose esophagoduodenstom was used to make the rat model of mixed reflux esophagitis.The pathohistologic examination was used to observe the changes in esophagus mucous membrane.The content of SP
NOS and VIP in the esophagus tissue was detected after 12 days by immunohistochemical technique.Result: Compared with the model group
the esophagus mucous membrane of the Tiaozhong Granule group
the Banxia Xiexin Tang group and cisapride group were renovated;the content of NOS and VIP in the rats of the Tiaozhong granule group
the Banxia Xiexin Tang group and cisapride group were increased significantly;and the content of SP decreased after treatment.The differences between the treatment groups were not significant.Conclusion: Tiaozhong granule can be applied for mixed reflux esophagitis through decreasing the content of NOS
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Related Author
FENG Yun-xia
SHI Zhao-hong
ZHANG Jie-mei
HAO Jian-jun
CHEN Zhou
ZHANG Shu
WANG Guangming
LIU Wanli
Related Institution
Nanjing Hospital (Nanjing First Hospital) affiliated to Nanjing Medical University
Nanjing Hospital of combination of Chinese traditional and western medicine
The First Affiliated Hospital of Guangxi University of TCM
Graduate School of Guangxi University of Traditional Chinese Medicine(TCM)