Effects of Water Extracts from Cassia obtusifolia on Blood Pressure,Blood Lipid and Renal Structure in Cold-induced Hypertensive Mice

PAN Zheng-jun; LU Qi; PAN Li; XU Xuan-xuan; PANG Jin-shui

doi:10.13422/j.cnki.syfjx.2010.15.067

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Effects of Water Extracts from Cassia obtusifolia on Blood Pressure,Blood Lipid and Renal Structure in Cold-induced Hypertensive Mice

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- Effects of Water Extracts from Cassia obtusifolia on Blood Pressure,Blood Lipid and Renal Structure in Cold-induced Hypertensive Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 15, Pages: 195-198(2010)
- 作者机构：
  
  淮阴师范学院生命科学学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.15.067
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]潘正军,陆祈,潘丽,徐璇璇,庞金水.决明子水提液对高血压小鼠血压血脂及肾脏结构的影响[J].中国实验方剂学杂志,2010,16(15):195-198.

PAN Zheng-jun, LU Qi, PAN Li, et al. Effects of Water Extracts from Cassia obtusifolia on Blood Pressure,Blood Lipid and Renal Structure in Cold-induced Hypertensive Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 195-198.
[1]潘正军,陆祈,潘丽,徐璇璇,庞金水.决明子水提液对高血压小鼠血压血脂及肾脏结构的影响[J].中国实验方剂学杂志,2010,16(15):195-198. DOI： 10.13422/j.cnki.syfjx.2010.15.067.

PAN Zheng-jun, LU Qi, PAN Li, et al. Effects of Water Extracts from Cassia obtusifolia on Blood Pressure,Blood Lipid and Renal Structure in Cold-induced Hypertensive Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 195-198. DOI： 10.13422/j.cnki.syfjx.2010.15.067.

摘要

目的:检测决明子水提液对冷激诱导的高血压小鼠血压、血脂及肾脏结构的影响。方法:制备决明子水提液备用。实验小鼠分为正常对照组、冷激对照组、冷激决明子饲喂组（5

20 mg.kg-1.BW）

对照组相应给予等量生理盐水

连续饲喂18 d。检测各组小鼠血压、血脂含量

切片观察肾脏结构。结果:冷激对照组血压显著高于正常对照组（P<0.01）

决明子水提液饲喂组小鼠的收缩压、舒张压、平均动脉压与正常对照组相比

差异不显著（P>0.05）。冷激对照组TG含量显著高于正常对照组（P<0.01）

而冷激饲喂组TG含量明显降低（P<0.05）;冷激饲喂（10 mg.kg-1

20 mg.kg-1）组TC含量降低（P<0.05）;冷激饲喂（10 mg.kg-1）组LDL与HDL含量均降低

其他饲喂组与冷激对照组相比含量虽有降低但无统计学意义。冷激对照组肾小管管壁水肿

内腔极度缩小

肾小球明显胀大

肾小囊腔显著变窄

决明子饲喂组肾小管水肿基本消失

内腔明显增大

肾小球、肾小囊结构趋于正常。结论:决明子水提液具有降血压、降血脂、改善病变肾脏结构的作用。

Abstract

Objective: To explore the effects of water extracts from Cassia obtusifolia on blood pressure

blood lipids and kidney structure in cold-induced hypertensive mice.Method: Water extracts from Cassia obtusifolia was prepared.Mice were divided into normal control group

cold-stress control group

and cold-stress feeding groups（water extracts 5

20 mg·kg-1）.Control groups were given physiological saline as the control.After 18 days

blood pressure was measured by carotid intubation and the contents of serum trireactive glyceride（TG）

total cholesterol（CHO）

low density lipoprotein（LDL）

high density lipoprotein（HDL） were also detected.Kidney was observed by routine histology inspection.Result: The blood pressure in cold-stress control group increased significantly compared with normal control group（P < 0.01）.Cold-stress feeding groups’systolic pressure

diastolic pressure and mean arterial pressure were not evident compared with normal control group.The content of TG in cold-stress control group was increased compared with that in normal control group（P < 0.01）

and the content of TG

TC in cold-stress feeding groups decreased compared with that in cold-stress control group（P < 0.05）.The content of LDL and HDL in cold-stress feeding group（10 mg.kg-1） decreased compared with that in cold-stress control group（P < 0.05）

and the others had no statistical significance compared with that in cold-stress control group.Renal histologic changes caused by cold-stress showed severely enlarged glomeruli

narrowed Bowman’s spaces

and renal tubule edema.Nephrons of the cold-stress feeding groups were similar to that of the control group.Conclusion: The water extracts from C.obtusifolia possesses the effects of decreasing blood pressure and modulating blood lipidcontents and improving pathological changes of renal structure.

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Related Author

PAN Zheng-jun

LU Qi

PAN Li

XU Xuan-xuan

PANG Jin-shui

WANG Lili

LI Qun

HU Zhixing

Related Institution

Wangjing Hospital， China Academy of Chinese Medical Sciences

Beijing University of Chinese Medicine Third Affiliated Hospital

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Guizhou University of Traditional Chinese Medicine

Fujian University of Traditional Chinese Medicine

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