YUAN Ji-cheng, YIN Yong-qin, SHEN Zhi-bin, et al. Effect of low Molecular Dextran on Pharmacokinetics of Xiangdan Injection in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 143-145.
YUAN Ji-cheng, YIN Yong-qin, SHEN Zhi-bin, et al. Effect of low Molecular Dextran on Pharmacokinetics of Xiangdan Injection in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 143-145. DOI: 10.13422/j.cnki.syfjx.2010.15.071.
Effect of low Molecular Dextran on Pharmacokinetics of Xiangdan Injection in Rats
Objective: To study effect of low molecular dextran on the pharmacokinetics of Xiangdan Injection in rats.Method:The rats were divided into two groups: one was administrated with Xiangdan Injection individually(group XD) and the other was administrated with the combination of Xiangdan Injection and low molecular dextran(group XD + DY).Plasma concentrations of danshensu of two groups were detected by HPLC.The pharmacokinetic parameters were calculated by software and statistical analysis.Result: The main pharmacokinetics parameters(α
t1/2α
CL
AUC(0-t) and K10) of danshensu had statistical differences between group XD and group XD + DY(P < 0.05).There were no significant differences in β
t1/2β
Vc
K12 and K21 between the two groups.Conclusion: There was obvious interaction of pharmacokinetics when the two drugs were used together.It is concluded that low molecular dextran inhibits the normal metabolism of danshensu of Xiangdan Iinjection.It is necessary to change the therapeutic dose of danshensu when the drug is coinjected with low molecular dextran.
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Related Author
YUAN Ji-cheng
YIN Yong-qin
SHEN Zhi-bin
DING Jin-long
ZENG Fan-lin
CHEN Chao
YU Meishuang
DAI Guoliang
Related Institution
Affiliated Hospital of Nanjing University of Chinese Medicine
Key Laboratory of Beijing for Identification and Safety of Chinese Medicine,State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
National & Local United Engineering Laboratory for TCM Advanced Manufacturing Technology, Tasly Pharmaceutical Co. Ltd.
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine (TCM)
Xiyuan Hospital, China Academy of Chinese Medical Sciences