CHEN Ting1, YAO Wei-feng1, ZHANG Li1, et al. UPLC-TOF-MS Based Metabonomic Study of CCl4-induced Rat-plasma Liver Injury[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 98-101.
CHEN Ting1, YAO Wei-feng1, ZHANG Li1, et al. UPLC-TOF-MS Based Metabonomic Study of CCl4-induced Rat-plasma Liver Injury[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 98-101. DOI: 10.13422/j.cnki.syfjx.2010.18.012.
UPLC-TOF-MS Based Metabonomic Study of CCl4-induced Rat-plasma Liver Injury
Objective:Use the metabonomics method to study the CCl4-induced liver injury model
and discriminate the potential biomarkers contributed to liver injury in plasma metabolites.Method:Adopt the metabolic skills based on UPLC-TOF-MS and PCA
to research the change of plasma metabolite in normal rat or CCl4-induced liver injury rat with two different doses.Result: Ascertain the CCl4 dosage in establish rat liver injury model of plasma metabolites and find ten characteristic biomakers in plasma.Conclusion: Metabonomics method was successfully used to study the CCl4-induced liver injury model by the rat plasma
and laid a foundation for the further study of the liver protection of Traditional Chinese Medicine.