Pharmacokinetcs in Rabbits after Intravenous Injection of Capsaicin Nanoemulsions and Soluion

ZHANG Peng-wei1; SU Wen-qin1; ZHANG Li2; XU Gui-hua3; LIU Ming-sheng1

doi:10.13422/j.cnki.syfjx.2010.18.014

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Pharmacokinetcs in Rabbits after Intravenous Injection of Capsaicin Nanoemulsions and Soluion

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- Pharmacokinetcs in Rabbits after Intravenous Injection of Capsaicin Nanoemulsions and Soluion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 18, Pages: 106-108(2010)
- 作者机构：
  
  1. 海南医学院药学院
  2. 武警医学院药剂教研室
  3. 罗田万密斋医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.18.014
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]张鹏威,苏文琴,张莉,徐贵华,刘明生.家兔静脉注射辣椒碱纳米乳及溶液的药动学比较研究[J].中国实验方剂学杂志,2010,16(18):106-108.

ZHANG Peng-wei1, SU Wen-qin1, ZHANG Li2, et al. Pharmacokinetcs in Rabbits after Intravenous Injection of Capsaicin Nanoemulsions and Soluion[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 106-108.
[1]张鹏威,苏文琴,张莉,徐贵华,刘明生.家兔静脉注射辣椒碱纳米乳及溶液的药动学比较研究[J].中国实验方剂学杂志,2010,16(18):106-108. DOI： 10.13422/j.cnki.syfjx.2010.18.014.

ZHANG Peng-wei1, SU Wen-qin1, ZHANG Li2, et al. Pharmacokinetcs in Rabbits after Intravenous Injection of Capsaicin Nanoemulsions and Soluion[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 106-108. DOI： 10.13422/j.cnki.syfjx.2010.18.014.

摘要

目的:建立HPLC-荧光法测定家兔血浆中辣椒碱含量

并比较家兔静脉注射辣椒碱纳米乳及辣椒碱溶液的药动学参数差异。方法:采用双周期交叉试验设计

6只家兔分别单剂量注射辣椒碱纳米乳及溶液

分别在给药后3

120 min时取血

以HPLC-荧光法测定血药浓度

并计算主要药动学参数。结果:辣椒碱在0.197～49.3 g.L-1（r=0.999 6）内线性良好

最低检测限为5.9 ng.mL-1

回收率为102.5%～107.6%

RSD<5%。辣椒碱纳米乳及溶液的消除半衰期t1/2分别为（11.77±2.32）min和（9.53±2.19）min

AUC为（5 311±1 324.6）ng.mL-1.kg-1.min和（4 909.5±1 110.4）ng.mL-1.kg-1.min。结论:HPLC-荧光法简便、准确、灵敏

适用于辣椒碱的血药浓度测定。家兔静脉注射辣椒碱纳米乳及溶液的主要药动学参数比较无显著性差异。

Abstract

Objective:To develop an HPLC-FLU method for the determination of capsaicin in rabbit plasma and to study its pharmacokinetics.Method: Six rabbits were given capsaicin nanoemulsions and ethanol solution（1mg.kg-1） via ear vein by double cycle crossover design

and after 3

60 and 120 min

blood samples were collected.HPLC-FLU was established to determine the plasma concentration of capsaicin and the pharmacokinetic evaluation was carried out.Result:The linear range of capsaicin was 0.197-49.3 mg.L-1（r = 0.999 6） and the limit of detection of capsaicin was 5.9 ng.mL-1

the average recovery was 102.5% ～ 107.6% with RSD < 5%.The t1/2 of capsaicin nanoemulsions and solution was（11.77 ± 2.32） min and（9.53 ± 2.19） min respectively

and the AUC was（5 311 ± 1 324.6） ng.mL-1.kg-1.min and（4 909.5 ± 1 110.4） ng.mL-1.kg-1.min respectively.Conclusion:This assay method is simple

precise and sensitive enough for the pharmacokinetic study of capsaicin.The pharmacokinectics parameters between capsaicin nanoemulsions and solution had no significant difference（t test

P > 0.05）.

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Related Author

ZHANG Peng-wei

SU Wen-qin

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LIU Ming-sheng

SUN Jing

QI Yunpeng

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Related Institution

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

First Teaching Hospital of Tianjin University of TCM

The Second Affiliated Hospital of Tianjin University of TCM

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

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