Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice

ZHANG Ran1; YUE Yong-hua1; KANG Yong1; SUN Guo-dong1; LI Hui-juan; JIAN Xiao-yong2; WANG Liu-gui2; QIN Xia3

doi:10.13422/j.cnki.syfjx.2010.18.022

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Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice

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- Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 18, Pages: 135-138(2010)
- 作者机构：
  
  1. 山西省中医药研究院
  2. 山西振东开元制药有限公司
  3. 太原理工大学校医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.18.022
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]张然,岳永花,康永,孙国栋,李慧娟,菅晓勇,王六贵,秦霞.扶正固本颗粒联合化疗放疗对于荷瘤小鼠的免疫增强作用[J].中国实验方剂学杂志,2010,16(18):135-138.

ZHANG Ran1, YUE Yong-hua1, KANG Yong1, et al. Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 135-138.
[1]张然,岳永花,康永,孙国栋,李慧娟,菅晓勇,王六贵,秦霞.扶正固本颗粒联合化疗放疗对于荷瘤小鼠的免疫增强作用[J].中国实验方剂学杂志,2010,16(18):135-138. DOI： 10.13422/j.cnki.syfjx.2010.18.022.

ZHANG Ran1, YUE Yong-hua1, KANG Yong1, et al. Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 135-138. DOI： 10.13422/j.cnki.syfjx.2010.18.022.

摘要

目的:研究扶正固本颗粒联合化疗、放疗的体内抗肿瘤作用及对荷瘤小鼠免疫功能的影响

并与单独放疗、化疗作比较。方法:建立小鼠肉瘤S180移植性肿瘤模型

次日随机分为10组

放、化疗

并ig给药每日1次

10 d后

计算抑瘤率、胸腺指数和脾指数

测定细胞因子白介素-2（IL-2）

白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平和外周血细胞数量

检测其抑瘤作用及对荷瘤小鼠免疫功能的影响。结果:联合治疗较单独的放化疗能增强荷瘤小鼠腹腔巨噬细胞吞噬功能

提高荷瘤小鼠的胸腺指数和脾脏指数;拮抗化疗所致荷瘤小鼠血清IL-2

IL-6和TNF-α的减少;拮抗放疗所致荷瘤小鼠外周血细胞的减少。结论:联合治疗可增强荷瘤小鼠免疫功能。

Abstract

Objective:To investigate the anti-tumor and immune effect of Fuzheng Guben Granule combined with chemotherapy and radiotherapy in tumor-bearing mice.Method:Tumor-bearing model of S180 sarcoma in mice was established by subcutaneous injection of S-180 ascites at armpit.On the next day

the mice were randomly divided into 10 groups

Fuzheng Guben Granule with radio-and chemotherapy was carried out once a day for ten days.Tumor inhibitory percentage

thymus gland

spleen indexes were then measured.The determination of cytokine

such as IL-2

IL-6

TNF-α and peripheral blood cell counts was made.The effect of treatment on tumor inhibition and immunological function was studied.Result:The combined therapy could significantly increase thymus gland

spleen indexes and improved the phagocytic function;antagonize serum IL-2

IL-6 and TNF-α reduction induced by chemotherapy;suppress the decrease in peripheral blood cells count induced by radiotherapy.Conclusion:Combinative therapy can enhance immune functions for S180-bearing mice.

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