Study on Influencing Factors on Release of Dracocephalum Total Flavones from HPMC Matrix Tablets

YANG Xiu1; XING Jian-guo2; WANG Xin-chun1; XUE Gui-peng2; MA Zu-wen1; REN Wen-dong1

doi:10.13422/j.cnki.syfjx.2010.18.054

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Study on Influencing Factors on Release of Dracocephalum Total Flavones from HPMC Matrix Tablets

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- Study on Influencing Factors on Release of Dracocephalum Total Flavones from HPMC Matrix Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 18, Pages: 6-9(2010)
- 作者机构：
  
  1. 石河子大学药学院
  2. 新疆维吾尔自治区药物研究所
  3. 石河子大学医学院一附院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.18.054
  CLC： R283
- Published：2010
- 稿件说明：
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[1]杨秀,邢建国,王新春,薛桂蓬,马祖文,任文东.香青兰总黄酮HPMC骨架片释放度的影响因素考察[J].中国实验方剂学杂志,2010,16(18):6-9.

YANG Xiu1, XING Jian-guo2, WANG Xin-chun1, et al. Study on Influencing Factors on Release of Dracocephalum Total Flavones from HPMC Matrix Tablets[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 6-9.
[1]杨秀,邢建国,王新春,薛桂蓬,马祖文,任文东.香青兰总黄酮HPMC骨架片释放度的影响因素考察[J].中国实验方剂学杂志,2010,16(18):6-9. DOI： 10.13422/j.cnki.syfjx.2010.18.054.

YANG Xiu1, XING Jian-guo2, WANG Xin-chun1, et al. Study on Influencing Factors on Release of Dracocephalum Total Flavones from HPMC Matrix Tablets[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 6-9. DOI： 10.13422/j.cnki.syfjx.2010.18.054.

摘要

目的:制备香青兰总黄酮HPMC（羟丙甲纤维素）骨架片

考察主要活性成分田薊苷体外释药的影响因素。方法:以HPMC为缓释骨架材料

采用湿法制粒压片法制备香青兰总黄酮骨架缓释片;测定香青兰总黄酮HPMC骨架片中主成分田薊苷在不同时间点的释放度

通过对体外释放曲线2

12 h累积释放度的综合评分K值及释放曲线相似因子f2的综合比较

考察影响田薊苷体外释药的因素。结果:骨架材料HPMC的种类及乳糖和淀粉的比例是影响田薊苷体外释放的主要因素。骨架材料HPMC的用量及粘合剂等因素对田薊苷释放的影响不大。结论:HPMC K15M能有效控制香青兰总黄酮缓释骨架片中主成分的释放。

Abstract

Objective:Total flavones sustainedrelease tablets of Dracocephalum were prepared and the influencing factors on release of the tilianin of Dracocephalum were studied.Method:The Dracocephalum total flavones sustainedrelease tablets were compressed after wet granulating the extracts of Dracocephalum total flavones with HPMC.Then

the influencing factors on release of tilianin were investigated by determining releaserate of tilianin at different time to draw release curve and calculate K value（a kind of index comprehended with cumulative release at 2

12 h

respectively） and f2（similar factorof release curve）.Result: The main influencing factors on releaserate of tilianin were the type of HPMC and the ratio of starch to lactose;the amount of HPMC and adhesive were the secondary.Conclusion: The release of tilianin of Saussurea involucrate could be controlled effectively by selecting HPMC K15M as matrices.

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REN Wen-dong

MA Zu-wen

XUE Gui-peng

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XING Jian-guo

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Related Institution

Tianjin Medical University

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