Investigation on Preparation of ZTO-containing Liposomes Composed of SPC and HSPC

CHENG Na-na; LU Tu-lin; CHEN Jun; MAO Chun-qin

doi:10.13422/j.cnki.syfjx.2010.18.056

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Investigation on Preparation of ZTO-containing Liposomes Composed of SPC and HSPC

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- Investigation on Preparation of ZTO-containing Liposomes Composed of SPC and HSPC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 18, Pages: 14-17(2010)
- 作者机构：
  
  南京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.18.056
  CLC： R283
- Published：2010
- 稿件说明：
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[1]程娜娜,陆兔林,陈军,毛春芹.莪术油复合磷脂脂质体的制备工艺[J].中国实验方剂学杂志,2010,16(18):14-17.

CHENG Na-na, LU Tu-lin, CHEN Jun, et al. Investigation on Preparation of ZTO-containing Liposomes Composed of SPC and HSPC[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 14-17.
[1]程娜娜,陆兔林,陈军,毛春芹.莪术油复合磷脂脂质体的制备工艺[J].中国实验方剂学杂志,2010,16(18):14-17. DOI： 10.13422/j.cnki.syfjx.2010.18.056.

CHENG Na-na, LU Tu-lin, CHEN Jun, et al. Investigation on Preparation of ZTO-containing Liposomes Composed of SPC and HSPC[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 14-17. DOI： 10.13422/j.cnki.syfjx.2010.18.056.

摘要

目的:采用复合磷脂脂质体技术制备莪术油脂质体并研究其最佳制备工艺及处方。方法:采用高效液相色谱法和分光光度法分别测定复合磷脂脂质体中莪术醇和莪术油的含量。采用乙醇注入法制备莪术油复合磷脂脂质体

并以脂质体中药物含量为考察指标

采用正交试验优选了莪术油复合磷脂脂质体的最优处方与工艺。结果:以优化的工艺和处方制备的莪术油复合磷脂脂质体

包封率稳定

药物含量高。结论:该脂质体制备方法准确可靠

工艺可行

质量稳定可控。

Abstract

Objective:To investigate the preparation of the novel liposome composed of hydrogenated soybean phosphatidylcholine（HSPC） and soybean phosphatidylcholine（SPC） containing zedoary turmeric oil（ZTO）.Method:HPLC analysis and spectrophotometry analysis were used to determine the contents of curcumol and ZTO in ZTO liposomes both composed of HSPC and SPC respectively.The ZTO novel liposomes were prepared by ethanol injection method.The best prescription of ZTO liposome both composed of HSPC and SPC was determined through orthogonal design

using the drug content of liposomes as the evaluation index.Result: When ZTO novel liposome was prepare with the best prescription

both the entrapment efficiency stability and the drug content were high.Conclusion: The method was accurate and applicable.The preparation was feasible and the quality of the novel liposome was stable and controllable.

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Related Author

CHENG Na-na

LU Tu-lin

Chen Jun

MAO Chun-qin

ZOU Linghui

YANG Xu

LI Jilang

DING Wenya

Related Institution

School of Pharmacy，Guangxi University of Chinese Medicine， South China Branch of National Engineering Research Center for Manufacturing Technology of Traditional Chinese Medicine Solid Preparation

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

School of Pharmacy， Jiangxi University of Chinese Medicine

School of Chinese Materia Medica， Tianjin University of Traditional Chinese Medicine

Key Laboratory of Applied Basic Research of Guangxi Zhuang Medicine，Guangxi University of Chinese Medicine

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