Optimization of Processing Parameters for Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule Using Box-Behnken Experimental Design

LIU Jun1; ZHANG Jian-jun2

doi:10.13422/j.cnki.syfjx.2011.01.015

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Optimization of Processing Parameters for Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule Using Box-Behnken Experimental Design

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- Optimization of Processing Parameters for Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule Using Box-Behnken Experimental Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 1, Pages: 9-13(2011)
- 作者机构：
  
  1. 广州中医药大学
  2. 广东省中医研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.01.015
  CLC： R284.2
- Published：2011
- 稿件说明：
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[1]柳俊,张建军.Box-Behnken效应面法优化白芍配方颗粒提取工艺[J].中国实验方剂学杂志,2011,17(01):9-13.

LIU Jun1, ZHANG Jian-jun2. Optimization of Processing Parameters for Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule Using Box-Behnken Experimental Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 9-13.
[1]柳俊,张建军.Box-Behnken效应面法优化白芍配方颗粒提取工艺[J].中国实验方剂学杂志,2011,17(01):9-13. DOI： 10.13422/j.cnki.syfjx.2011.01.015.

LIU Jun1, ZHANG Jian-jun2. Optimization of Processing Parameters for Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule Using Box-Behnken Experimental Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 9-13. DOI： 10.13422/j.cnki.syfjx.2011.01.015.

摘要

目的:优选白芍配方颗粒中白芍总苷提取的工艺条件。方法:采用单因素试验结合Box-Behnken效应面法

以白芍总苷提取量为指标进行试验

考察加水量、提取时间、提取温度、提取次数、浸泡时间等因素对提取工艺的影响。结果:优选出水提白芍总苷的最佳工艺为:浸泡98.4 min

加12倍量水

煎煮提取2次

每次69.8 min。白芍总苷的提取率为2.387 1%。结论:Box-Behnken试验设计法用于白芍配方颗粒提取工艺的优选是可行的

数学模型的预测值与试验观察值相符。

Abstract

Objective:Optimization of the processing parameters was applied for the extraction of total glucoside of paeony in paeony dispensing granule.Method: Based on the results of single-factor-at-a-time-technique

Box-Behnken experimental design combining with response surface methodology（RSM） was employed

with the soaking time（X1）

the water addition（X2）

the extraction time（X3） as the independent variables.The response variable was the amount of total glucoside of paeony.Result:The optimization processing parameters was as follows: X1

X2 and X3 levels of 98.4 min

12 times and 69.8 min respectively.Conclusion:The observed responses were in close agreement with the predicted values of the mathematic models

and the Box-Behnken experimental design is suitable for optimizing the extraction of total glucoside of paeony in paeony dispensing granule.

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Related Author

LIU Jun

ZHANG Jian-jun

Ren-guang WANG

Ai-ling JIA

Zhi-dong QIU

Jing-yao YANG

Xin-shu ZHANG

Ji-qi YANG

Related Institution

College of Pharmacy, Chengdu University of TCM

Key Laboratory of Active Ingredients in Traditional Chinese Medicine(TCM) Co-constructed by Jilin Province and Ministry of Education, Changchun University of Chinese Medicine

Research and Development Centre of New Drugs,Guangxi University of Chinese Medicine

Guangxi Bonger Pharmaceuticals Co.Ltd

Dongguan Hospital of Traditional Chinese Medicine

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