Simultaneous Analysis of Anthraquinones in Processed Pieces and Crude Drugs from Morinda officinalis

JIANG Yong-liang1; YANG Dan1; ZHANG Fan1; SHI Ji1; JIA Tian-zhu1

doi:10.13422/j.cnki.syfjx.2011.01.032

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Simultaneous Analysis of Anthraquinones in Processed Pieces and Crude Drugs from Morinda officinalis

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- Simultaneous Analysis of Anthraquinones in Processed Pieces and Crude Drugs from Morinda officinalis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 1, Pages: 64-66(2011)
- 作者机构：
  
  1. 辽宁中医药大学
  2. 辽宁省中药炮制工程技术研究中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.01.032
  CLC： R284.1
- Published：2011
- 稿件说明：
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[1]姜永粮,杨丹,张凡,史辑,贾天柱.巴戟天炮制前后蒽醌类成分含量变化[J].中国实验方剂学杂志,2011,17(01):64-66+69.

JIANG Yong-liang1, YANG Dan1, ZHANG Fan1, et al. Simultaneous Analysis of Anthraquinones in Processed Pieces and Crude Drugs from Morinda officinalis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 64-66.
[1]姜永粮,杨丹,张凡,史辑,贾天柱.巴戟天炮制前后蒽醌类成分含量变化[J].中国实验方剂学杂志,2011,17(01):64-66+69. DOI： 10.13422/j.cnki.syfjx.2011.01.032.

JIANG Yong-liang1, YANG Dan1, ZHANG Fan1, et al. Simultaneous Analysis of Anthraquinones in Processed Pieces and Crude Drugs from Morinda officinalis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 64-66. DOI： 10.13422/j.cnki.syfjx.2011.01.032.

摘要

目的:对巴戟天炮制前后3种蒽醌类化学成分的含量进行比较研究。方法:采用HPLC同时测定3种蒽醌类成分1

8-二羟基-3-羟甲基蒽醌

8-二羟基-3-甲基-5-羟甲基蒽醌

1-甲基蒽醌的含量

色谱柱:Agilent-C18（4.6 mm×150 mm

5μm）;流动相以甲醇-水梯度洗脱（60∶40→85∶15

25 min）;流速1.00 mL·min-1;柱温30℃;检测波长278 nm;进样量10μL。测定巴戟天生品和炮制品中三种蒽醌的含量。结果:3种蒽醌的线性范围分别为1

8-二羟基-3-羟甲基蒽0.019 9～0.199 2μg

8-二羟基-3-甲基-5-羟甲基蒽醌0.0331～0.331 2μg

1-甲基蒽醌0.0197～0.196 8μg

3种蒽醌的平均回收率均在98.50%～100.31%。巴戟天炮制前后蒽醌类成分有所变化。结论:所建立的分析方法可以同时测定巴戟天不同炮制品3种蒽醌类化合物的含量

为解析巴戟天炮制原理提供一定的科学依据。

Abstract

Objective:To compare the content of anthraquinones in the different processed products from Morinda officinalis How.Method: 1-methylanthraquinone

8-dihydroxy-3-methyl-5-hydroxymethyl-anthraquinone

8-dihydroxy-3-hydroxymethyl-anthraquinone were determined simultaneously by HPLC.The separation was performed on a Agilent C18 column at 30 ℃ with MeOH-H20（60:40→85:15

25 min） as a mobile phase.The detection wavelength was set at 278 nm and the flow rate was 1.00 mL.min-1.Result: Three components were linear within the range of 0.019 9-0.199 2 μg

0.0331-0.3312 μg

0.019 7-0.196 8 μg

and the average recoveries were 98.50%-100.31% respectively.Conclusion: The method can be used for evaluating the quality in different processed pieces of M.officinalis.

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