Determination of Notoginsenoside R1,Ginsenoside Rg1 and Ginsenoside Rb1 in Sanqi Zhixue Capsule by HPLC-ELSD

BI Xiao-li; LUO Wen-hui; LI Su-mei

doi:10.13422/j.cnki.syfjx.2011.01.035

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Determination of Notoginsenoside R₁,Ginsenoside Rg₁ and Ginsenoside Rb₁ in Sanqi Zhixue Capsule by HPLC-ELSD

更新时间：2024-09-23

- Determination of Notoginsenoside R₁,Ginsenoside Rg₁ and Ginsenoside Rb₁ in Sanqi Zhixue Capsule by HPLC-ELSD
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 1, Pages: 75-77(2011)
- 作者机构：
  
  广东省中医研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.01.035
  CLC： R284.1
- Published：2011
- 稿件说明：
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[1]毕晓黎,罗文汇,李素梅.HPLC-ELSD法测定三七止血胶囊中三七皂苷R_1、人参皂苷Rg_1和人参皂苷Rb_1的含量[J].中国实验方剂学杂志,2011,17(01):75-77.

BI Xiao-li, LUO Wen-hui, LI Su-mei. Determination of Notoginsenoside R₁,Ginsenoside Rg₁ and Ginsenoside Rb₁ in Sanqi Zhixue Capsule by HPLC-ELSD[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 75-77.
[1]毕晓黎,罗文汇,李素梅.HPLC-ELSD法测定三七止血胶囊中三七皂苷R_1、人参皂苷Rg_1和人参皂苷Rb_1的含量[J].中国实验方剂学杂志,2011,17(01):75-77. DOI： 10.13422/j.cnki.syfjx.2011.01.035.

BI Xiao-li, LUO Wen-hui, LI Su-mei. Determination of Notoginsenoside R₁,Ginsenoside Rg₁ and Ginsenoside Rb₁ in Sanqi Zhixue Capsule by HPLC-ELSD[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 75-77. DOI： 10.13422/j.cnki.syfjx.2011.01.035.

摘要

目的:采用高效液相色谱法-蒸发光散射检测器（HPLC-ELSD）测定三七止血胶囊中三七皂苷R1、人参皂苷Rg1和人参皂苷Rb1的含量。方法:以乙腈-水为流动相梯度洗脱（0～12 min

乙腈19%→36%）

Hypersil ODS柱（4.0 mm×200mm

5μm）为固定相

流速为1.0 mL·min-1

ELSD参数:漂移管温度45℃

载气流量1.5 L·min-1。结果:三七皂苷R1、人参皂苷Rg1和人参皂苷Rb1的回收率分别为97.86%

96.24%和97.58%

RSD分别为1.36%

1.58%和1.13%（n=6）。结论:该方法简便、快速、重现性好

可用于三七止血胶囊的质量控制。

Abstract

Objective:To develop an HPLC-ELSD method for the content determination of notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 in Sanqi Zhixue Capsule.Method: The analysis was carried out on a Hypersil ODS analytical column（4.6 mm × 200 mm

5 μm） with the mobile phase consisting of acetonitrile-water by gradient elution（0-12 min

acetonitrile 19% →36%）.The detector drift tube temperature was set at 45 ℃ and the nitrogen flow rate was 1.5 L·min-1.Result: The recoveries for notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 were 97.86%

96.24% and 97.58% with RSD 1.36%

1.58% and 1.13%（n = 6） respectively.Conclusion: The developed method is simple

rapid

replicable

and can be used for the quality control of Sanqi Zhixue Capsule.

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Related Author

BI Xiao-li

LUO Wen-hui

LI Su-mei

LI Yu-cui

CHEN Zhi-wei

BAO Mei-jia

HU Jia-min

PENG Shao-zhong

Related Institution

Guangzhou University of Chinese Medicine

Guangdong Industry Technical College

School of Chinese Materia Medica,Haerbin University of Commerce,Haerbin

College of Traditional Chinese Medicine,Hebei United University

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