Comparative Studies on Pharmacological Effects between Extracts from Cultural and Wild Radix Sophorae Flavescentis

ZHU Jing-jing; XIA Bo-hou; WANG Jin-hua; ZHANG Qing-zhe; WANG Zhi-min; CAO Lin-li

doi:10.13422/j.cnki.syfjx.2011.01.040

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Comparative Studies on Pharmacological Effects between Extracts from Cultural and Wild Radix Sophorae Flavescentis

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- Comparative Studies on Pharmacological Effects between Extracts from Cultural and Wild Radix Sophorae Flavescentis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 1, Pages: 96-99(2011)
- 作者机构：
  
  中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.01.040
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]朱晶晶,夏伯侯,王金华,张清哲,王智民,曹伶俐.栽培苦参与野生苦参的药效学研究[J].中国实验方剂学杂志,2011,17(01):96-99.

ZHU Jing-jing, XIA Bo-hou, WANG Jin-hua, et al. Comparative Studies on Pharmacological Effects between Extracts from Cultural and Wild Radix Sophorae Flavescentis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 96-99.
[1]朱晶晶,夏伯侯,王金华,张清哲,王智民,曹伶俐.栽培苦参与野生苦参的药效学研究[J].中国实验方剂学杂志,2011,17(01):96-99. DOI： 10.13422/j.cnki.syfjx.2011.01.040.

ZHU Jing-jing, XIA Bo-hou, WANG Jin-hua, et al. Comparative Studies on Pharmacological Effects between Extracts from Cultural and Wild Radix Sophorae Flavescentis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 96-99. DOI： 10.13422/j.cnki.syfjx.2011.01.040.

摘要

目的:比较栽培与野生苦参的清热、利尿、镇痛方面的药效学作用。方法:以干酵母致大鼠高热模型比较栽培苦参与野生苦参的解热作用;以代谢笼收集大鼠不同时间点的排尿量和总尿量比较栽培与野生苦参的利尿效果;采用热板和扭体法比较观察其对小鼠的镇痛作用。结果:栽培与野生苦参（1

4 g.kg-1剂量）均能明显降低酵母菌致热模型大鼠的体温;明显增加大鼠不同时间段的排尿量和排尿总量;栽培与野生苦参3

6 g.kg-1剂量均可明显提高小鼠的热板痛阈值、明显延长小鼠出现扭体的潜伏期并明显减少小鼠的扭体次数

表明其具有非常明显的镇痛作用。结论:栽培苦参与野生苦参都具有明显的清热、利尿和镇痛方面的作用

药效学作用强度比较野生与栽培苦参无显著差异

本实验结果为栽培苦参代替野生苦参提供了实验依据。

Abstract

Objective: To compare antipyretic

diuretic

anti-tumor and analgesic effects of extracts from cultural and wild Radix Sophorae Flavescentis.Method: The antipyretic action was monitored by dried yeastinduced fever in rats.The diuretic effect was observed in mouse model by collecting and testing urine volumes in different intervals.The analgesic effects were discussed by adopting acetic acid writhing and hot plate test in mice.Result: Both the extracts from cultural and wild Radix Sophorae Flavescentis 1

4 g·kg-1 significantly reduced the fever induced by dried yeast and increased urine volumes in rats at all the intervals.Both of them 3

6 g.kg-1 remarkably enhanced the threshold of pain by hot plate

reduced the numbers of writhing and prolonged the latencies of paw licking in mice

showing significant analgesic effects.Conclusion: There is no significant difference in antipyretic

diuretic and analgesic effects between extracts from cultural and wild Sophorae flavescentis.The results provide experimental evidence for cultural Sophorae flavescentis replacing wild ones in clinic.

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Related Author

CAO Lin-li

WANG Zhi-min

ZHANG Qing-zhe

WANG Jin-hua

XIA Bo-hou

ZHU Jing-jing

Yan-ling LI

Hong-miao LIU

Related Institution

The First Hospital of Hebei Medical University

Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. Ltd., China Shijiazhuang Pharmaceutical Group Co. Ltd.

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