Effect of Alpinia officinarum Extract on Brain Vascular Permeability in Mice

ZHAO Yan-yan1; LIU Xin-xia2; CHEN Chun-sheng3; BAI Jie1

doi:10.13422/j.cnki.syfjx.2011.01.052

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Effect of Alpinia officinarum Extract on Brain Vascular Permeability in Mice

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- Effect of Alpinia officinarum Extract on Brain Vascular Permeability in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 1, Pages: 142-144(2011)
- 作者机构：
  
  1. 河北大学医学实验中心
  2. 河北大学化学与环境科学学院
  3. 河北大学医学部
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.01.052
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]赵燕燕,刘新霞,陈春生,白洁.高良姜不同提取物对急性脑缺血小鼠脑血管通透性的影响[J].中国实验方剂学杂志,2011,17(01):142-144.

ZHAO Yan-yan1, LIU Xin-xia2, CHEN Chun-sheng3, et al. Effect of Alpinia officinarum Extract on Brain Vascular Permeability in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 142-144.
[1]赵燕燕,刘新霞,陈春生,白洁.高良姜不同提取物对急性脑缺血小鼠脑血管通透性的影响[J].中国实验方剂学杂志,2011,17(01):142-144. DOI： 10.13422/j.cnki.syfjx.2011.01.052.

ZHAO Yan-yan1, LIU Xin-xia2, CHEN Chun-sheng3, et al. Effect of Alpinia officinarum Extract on Brain Vascular Permeability in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 142-144. DOI： 10.13422/j.cnki.syfjx.2011.01.052.

摘要

目的:研究高良姜不同提取物对急性脑缺血小鼠脑血管通透性的影响。方法:昆明种小鼠随机分为9组:空白对照组、模型对照组、尼莫地平组、高良姜水提取物（WEAH）6.66

3.33

1.67 mg·kg-1组、高良姜乙醇提取物（EEAH）6.66

3.33

1.67 mg·kg-1组。连续ig 10 d后

采用双侧颈总动脉结扎法制备小鼠急性脑缺血模型

干湿重法观察脑含水量变化

通过收集透出脑血管外的伊文思蓝（Evans blue

EB）含量考察脑血管通透性的变化。结果:急性脑缺血发生后3 h

模型组小鼠与空白对照组相比较

脑含水量及脑组织内EB含量显著增加（P<0.05）。与模型组比较

尼莫地平组小鼠脑含水量及脑组织内EB含量均显著降低（P<0.05）;高良姜水提取物6.66 mg·kg-1、乙醇提取物3.33 mg·kg-1及1.67 mg·kg-1组小鼠脑含水量显著降低（P<0.05）;高良姜水提取物3个剂量组小鼠脑组织内EB含量均显著降低（P<0.05）

乙醇提取物组小鼠脑组织内EB含量有降低趋势

但无显著性差异。结论:高良姜水及乙醇提物可有效降低急性脑缺血后脑含水量和脑血管的通透性

对脑血管有一定的保护作用。

Abstract

Objective: To observe the effect of Alpinia officinarum extract on blood vessel of brain permeability.Method:Kunming mice were randomly divided into 9 groups（control group

model group

nimodipine group

watere xtract of A.officinarum 6.66

3.33

1.67 mg·kg-1 groups

Ethanol extract of A.officinarum 6.66

3.33

1.67 mg·kg-1 groups）.The mice model of total cerebral ischemia was established with method of bilateral common carotid artery occlusion after 10 days of ig treatment.The brain water content was evaluated by detecting the wet weight and dry weight of brain;The detection of cerebral extra-vascular Evans blue（EB） content was used to observe the changes of cerebrovascular permeability.Result: After acute cerebral ischemia for 3 hours

compared with the control group

brain water content and EB content of brain tissue increased significantly（P < 0.05） in the model control group mice.Compared with the model group

the brain water content and EB content of brain tissue were significantly decreased（P < 0.05） in nimodipine group;the brain water content were significantly decreased （P < 0.05） in WEAH 6.66 mg·kg-1

EEAH 3.33 mg·kg-1 and 1.67 mg·kg-1;brain tissue EB content were significantly decreased（P < 0.05） in three doses of aqueous extract groups.Conclusion:WEAH and EEAH can decrease the cerebral water content and cerebrovascular permeability effectively.

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