Studies on Preparation of Bergenin Solid Dispersion Osmotic Pump Tablets

WU Min1; YIN Rong-li2; LI Quan1; HUANG Mei1; LI Jie1

doi:10.13422/j.cnki.syfjx.2011.02.003

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Studies on Preparation of Bergenin Solid Dispersion Osmotic Pump Tablets

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- Studies on Preparation of Bergenin Solid Dispersion Osmotic Pump Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 35-39(2011)
- 作者机构：
  
  1. 成都医学院药学院
  2. 成都中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.003
  CLC： TQ461
- Published：2011
- 稿件说明：
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[1]吴敏,尹蓉莉,李全,黄梅,李洁.岩白菜素固体分散体渗透泵片制备工艺[J].中国实验方剂学杂志,2011,17(02):35-39.

WU Min1, YIN Rong-li2, LI Quan1, et al. Studies on Preparation of Bergenin Solid Dispersion Osmotic Pump Tablets[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 35-39.
[1]吴敏,尹蓉莉,李全,黄梅,李洁.岩白菜素固体分散体渗透泵片制备工艺[J].中国实验方剂学杂志,2011,17(02):35-39. DOI： 10.13422/j.cnki.syfjx.2011.02.003.

WU Min1, YIN Rong-li2, LI Quan1, et al. Studies on Preparation of Bergenin Solid Dispersion Osmotic Pump Tablets[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 35-39. DOI： 10.13422/j.cnki.syfjx.2011.02.003.

摘要

目的:利用固体分散技术改善微溶性药物岩白菜素的体外溶出行为

进而考察片芯及包衣处方对岩白菜素固体分散体渗透泵片体外释药行为的影响

并优选最佳片芯及包衣处方。方法:采用熔融法制备岩白菜素固体分散体

并测定其溶出速率和溶解度;根据不同时间的累积释放度

考察药物的释放情况

通过单因素考察及正交试验设计优化片芯及包衣处方。结果:包衣膜中增塑剂的用量对岩白菜素固体分散体渗透泵片体外释药行为有影响。最后所得处方可在12 h内稳定释药且累积释放度可达到90%以上。结论:以岩白菜素固体分散体为中间体制成单室单层渗透泵片

其释药行为符合一级动力学过程。

Abstract

Objective:To improve the dissolution character in vitro of slightly soluble bergenin by using solid dispersion technology

and investigate the effect of the formulation of core tablets and coating on bergenin solid dispersion osmotic pump tablets release in vitro and optimize the formulation.Method:The bergenin solid dispersion was prepared by fusion method

and the phase solubility and dissolution test was also determined.The release in vitro was studied through cumulative release measuring.And the optimal formulation of bergenin solid dispersion osmotic pump tablets was selected via the single-factor method and orthogonal design.Result: The amount of plasticizer was found to have effect on release in vitro of bergenin solid dispersion osmotic pump tablets.The tablets with optimized formulation could achieve the desired one-order release profile during 12 hours and the cumulative release over 90 percent.Conclusion:The release behavior of the monolithic osmotic pump tablets based on the intermediat of bergenin solid dispersion followed one-order kinetics equation.

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Related Author

WU Min

YIN Rong-li

LI Quan

HUANG Mei

LI Jie

LIU Man

YANG Ying

JI Jing

Related Institution

Jiangsu Province Engineering Research Center of Famous Classical Formulas，School of Pharmacy，Nanjing University of Chinese Medicine

Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences

Chengdu University of Traditional Chinese Medicine

Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Engineering Training Center,Shijiazhuang Railway University

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