Gentianopsis paludosa Extract for Treatment of Experimental Ulcerative Colitis in Mice

JING Ming; LUO Yong-jiao; CHEN Zheng-jun; LIN Xing-yao

doi:10.13422/j.cnki.syfjx.2011.02.006

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Gentianopsis paludosa Extract for Treatment of Experimental Ulcerative Colitis in Mice

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- Gentianopsis paludosa Extract for Treatment of Experimental Ulcerative Colitis in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 113-116(2011)
- 作者机构：
  
  甘肃中医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.006
  CLC： R29
- Published：2011
- 稿件说明：
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[1]景明,罗永皎,陈正君,蔺兴遥.藏药湿生扁蕾提取物治疗小鼠溃疡性结肠炎的研究[J].中国实验方剂学杂志,2011,17(02):113-116.

JING Ming, LUO Yong-jiao, CHEN Zheng-jun, et al. Gentianopsis paludosa Extract for Treatment of Experimental Ulcerative Colitis in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 113-116.
[1]景明,罗永皎,陈正君,蔺兴遥.藏药湿生扁蕾提取物治疗小鼠溃疡性结肠炎的研究[J].中国实验方剂学杂志,2011,17(02):113-116. DOI： 10.13422/j.cnki.syfjx.2011.02.006.

JING Ming, LUO Yong-jiao, CHEN Zheng-jun, et al. Gentianopsis paludosa Extract for Treatment of Experimental Ulcerative Colitis in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 113-116. DOI： 10.13422/j.cnki.syfjx.2011.02.006.

摘要

目的:观察藏药湿生扁蕾提取物（GTP）对小鼠实验性溃疡性结肠炎的治疗作用。方法:用三硝基苯磺酸（TNBS）/乙醇灌肠制作小鼠实验性溃疡性结肠炎（UC）模型

小鼠ig给予GTP（1.07

2.14

4.28 g.kg-1）

连续14 d

观察对小鼠体质量变化、腹泻、结肠黏膜组织形态学及脾脏指数的影响。结果:湿生扁蕾提取物可不同程度地改善由TNBS的乙醇溶液所致UC小鼠体质量下降及腹泻症状

显著降低UC小鼠大体形态学损伤的肠黏膜粘连及其溃疡分值

明显抑制UC小鼠脾脏肿大。结论:湿生扁蕾提取物对小鼠溃疡性结肠炎有较好的改善作用

能减轻结肠局部的病理性损伤。

Abstract

Objective: Therapeutic effects of the extract from Gentianopsis paludosa on experimental ulcerative colitis were observed in mice.Method:Experimental ulcerative colitis（UC） was made by trinitrobenzene sulfonic acid（TNBS） /ethanol enema in mice.Animals were fed with GTP（1.07

2.14

4.28 g·kg-1） ig for continuous 14d.Changes in body weight

diarrhea

histomorphology of colonic mucosa and spleen index of morphology were observed.Result: The extract from G.paludosa could improve diarrhea and worsening of body constitution to varying degrees in the animals with UC induced by trinitrobenzenesulfonic acid（TNBS） solution of ethanol

and significantly alleviate gross morphological damage and intestinal adhesion

improve ulcer scores

and significantly inhibit spleen enlargement.Conclusion: The extract from G.paludosa of offers beneficial function for ulcerative colitis in mice

and can reduce pathological damage in colonic tissues.

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