Detection of Salbutamol in some Cough Preparations of Traditional Chinese Medicine by HPLC

CHENG Qi-lai; LI Hong-liang; ZHANG Dao-ying

doi:10.13422/j.cnki.syfjx.2011.02.029

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Detection of Salbutamol in some Cough Preparations of Traditional Chinese Medicine by HPLC

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- Detection of Salbutamol in some Cough Preparations of Traditional Chinese Medicine by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 80-82(2011)
- 作者机构：
  
  赣南医学院药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.029
  CLC： R286
- Published：2011
- 稿件说明：
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[1]程齐来,李洪亮,张道英.HPLC检测止咳中药制剂中的沙丁胺醇[J].中国实验方剂学杂志,2011,17(02):80-82.

CHENG Qi-lai, LI Hong-liang, ZHANG Dao-ying. Detection of Salbutamol in some Cough Preparations of Traditional Chinese Medicine by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 80-82.
[1]程齐来,李洪亮,张道英.HPLC检测止咳中药制剂中的沙丁胺醇[J].中国实验方剂学杂志,2011,17(02):80-82. DOI： 10.13422/j.cnki.syfjx.2011.02.029.

CHENG Qi-lai, LI Hong-liang, ZHANG Dao-ying. Detection of Salbutamol in some Cough Preparations of Traditional Chinese Medicine by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 80-82. DOI： 10.13422/j.cnki.syfjx.2011.02.029.

摘要

目的:建立检测止咳中药制剂中非法掺入的化学止咳平喘药物沙丁胺醇方法。方法:选用Agilent C18（4.6 mm×150 mm

5μm）

以甲醇-磷酸二氢钾溶液（用磷酸调节pH 3.0）5∶95为流动相。根据所检测到化合物的色谱保留时间

并与对照品比较

鉴别中药制剂中非法掺入的沙丁胺醇。结果:本实验建立的条件能够把中药制剂中添加的化学药物（沙丁胺醇）完全分离开来;对20个制剂样品用建立的分析技术进行了检测

经与相应的对照品比较

20个样品均未检测到沙丁胺醇。结论:该方法选择性强

灵敏度高

可作为中药制剂中非法加入掺入化学药物成分沙丁胺醇的有效检测手段。

Abstract

Objective:To develop a quantification method for the detection of salbutamol

a cough medicine

adulterated illegally in some cough preparations of traditional Chinese medicine.Method:Salbutamol was detected by HPLC on an Agilent Eclipse XDB-C18 column（4.6 mm × 150 mm

5 μm） with methanol-potassium dihydrogen phosphate（adjust pH to 7.0 with phosphoric acid）（5∶95） as a mobile phase.According to the detected compound retention time

compared with the reference substance

the chemical drug salbutamol that was adulterated illegally into TCM preparations could be identified.Result:The conditions developed in this study could entirely separate from the cough medicine salbutamol added into TCM preparations.Using this method to detect 20 kinds of preparations and compared with the corresponding standard substances

salbutamol was not detected in 20 kinds of samples.Conclusion:The method is selective

sensitive and can be used as an effective means to detect illegal TCM preparation.

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