Effects of Huanglian Jiedu Decoction on Prothrombotic State in Spontaneous Hypertension Rats

ZHANG Zhi-wei; YUE Gui-hua; LUO Yuan

doi:10.13422/j.cnki.syfjx.2011.02.034

您当前的位置：

首页 >

文章列表页 >

Effects of Huanglian Jiedu Decoction on Prothrombotic State in Spontaneous Hypertension Rats

更新时间：2024-09-23

- Effects of Huanglian Jiedu Decoction on Prothrombotic State in Spontaneous Hypertension Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 105-108(2011)
- 作者机构：
  
  广西中医学院附属瑞康医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.034
  CLC： R285.5
- Published：2011
- 稿件说明：
移动端阅览
[1]张志伟,岳桂华,罗远.黄连解毒汤对自发性高血压大鼠血栓前状态的影响[J].中国实验方剂学杂志,2011,17(02):105-108.

ZHANG Zhi-wei, YUE Gui-hua, LUO Yuan. Effects of Huanglian Jiedu Decoction on Prothrombotic State in Spontaneous Hypertension Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 105-108.
[1]张志伟,岳桂华,罗远.黄连解毒汤对自发性高血压大鼠血栓前状态的影响[J].中国实验方剂学杂志,2011,17(02):105-108. DOI： 10.13422/j.cnki.syfjx.2011.02.034.

ZHANG Zhi-wei, YUE Gui-hua, LUO Yuan. Effects of Huanglian Jiedu Decoction on Prothrombotic State in Spontaneous Hypertension Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 105-108. DOI： 10.13422/j.cnki.syfjx.2011.02.034.

摘要

目的:观察黄连解毒汤对自发性高血压大鼠（spontaneously hypertensive rats

SHR）血栓前状态（prothromboticstate

PTS）的影响。方法:24只12周龄雄性SHR随机分为黄连解毒汤组（15 g·kg-1）、卡托普利组（0.0175 g·kg-1）和模型组3组

8只同龄雄性Wistar-Kyoto（WKY）大鼠为空白对照组

通过BP-6动物无创血压测试仪测定各组治疗前血压

连续ig给药6周

每日1次

第1

6周的第7天下午定时测量各组血压

6周后由腹主动脉取血

检测血清血栓素A2（TXA2）

6-酮前列环素（6-K-PG）

一氧化氮（NO）

内皮素-1（ET-1）

纤溶系统激活剂（t-PA）

纤溶系统抑制因子（PAI-1）

同型半胱氨酸（Hcy）和血管性血友病因子（vWF）。结果:黄连解毒汤可控制SHR血压

降低TXA2

ET-1

Hcy和vWF（P<0.05或P<0.01）

增加6-K-PG和NO（P<0.05或P<0.01）。结论:黄连解毒汤可降低SHR的血压

改善其PTS。

Abstract

Objective:To observe the effects of Huanglian Jiedu Decoction on prothrombotic state（PTS） in spontaneous hypertension rats（SHR）.Method:Twenty-four SHR were randomly divided into the Huanglian Jiedu Decoction treated group

captopril treated group and model group;eight Wistar-Kyoto Rats were used as the blank group.The groups were treated by Huanglian Jiedu Decoction

captopril and distilled water respectively for six weeks.Blood pressure（BP） were measured at the beginning of the experiment and the end of every week in the experiment

and after six weeks

thromboxane A2（TXA2）

6-Keto-prostaglandin（6-K-PG）

nitric oxide（NO）

endothelin-1（ET-1）

tissue type plasminogen activator（t-PA）

Plasminogen activator inhibitor-1（PAI-1）

homocysteic acid（Hcy） and von Willebrand factor（vWF） of plasma were determined respectively.Result: Huanglian Jiedu Decoction could control the BP of the SHR and decrease the content of TXA2

ET-1

Hcy

vWF（P < 0.05 or P < 0.01） and increase the content of 6-K-PG

NO（P < 0.05 or P < 0.01）.Conclusion:Huanglian Jiedu Decoction could control the BP and improve the PTS in the SHR.

关键词

Keywords

references

Views

306

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Erxiantang on Cardiac Function and Blood Pressure Dynamic Evolution in Ovariectomized Rats

Experiment Studies on Dual-directional Regulation of Guizhitang for Rat Blood Pressure and Its Active Fractions of Guizhitang

The Optimization of Extracting Mode of Huanglian Jiedu Decoction Using Semi-bionic Extraction Method

Related Author

ZHANG Zhi-wei

YUE Gui-hua

LUO Yuan

Yu-han WANG

Yan-hua JIANG

Li-hua XIANG

Yan-jun LIU

Zhi-guo ZHANG

Related Institution

Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine

The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

School of Pharmaceutical Sciences,Jilin University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰