Studies on Anti-inflammatory Mechanism of Polygala japonica Effective Ingredients in Vitro

ZHAO Qing-chao1; HUANG Xian-zhang1; HU Jiu-lue1; YUAN Lin2; MAO Bing-yu1

doi:10.13422/j.cnki.syfjx.2011.02.040

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Studies on Anti-inflammatory Mechanism of Polygala japonica Effective Ingredients in Vitro

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- Studies on Anti-inflammatory Mechanism of Polygala japonica Effective Ingredients in Vitro
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 131-134(2011)
- 作者机构：
  
  1. 南阳理工学院张仲景国医学院
  2. 湖北中医药大学“中药资源与中药复方”省部共建教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.040
  CLC： R285.5
- Published：2011
- 稿件说明：
移动端阅览
[1]赵清超,黄显章,胡久略,袁林,毛秉豫.瓜子金有效部位群抗炎作用机制研究[J].中国实验方剂学杂志,2011,17(02):131-134.

ZHAO Qing-chao1, HUANG Xian-zhang1, HU Jiu-lue1, et al. Studies on Anti-inflammatory Mechanism of Polygala japonica Effective Ingredients in Vitro[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 131-134.
[1]赵清超,黄显章,胡久略,袁林,毛秉豫.瓜子金有效部位群抗炎作用机制研究[J].中国实验方剂学杂志,2011,17(02):131-134. DOI： 10.13422/j.cnki.syfjx.2011.02.040.

ZHAO Qing-chao1, HUANG Xian-zhang1, HU Jiu-lue1, et al. Studies on Anti-inflammatory Mechanism of Polygala japonica Effective Ingredients in Vitro[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 131-134. DOI： 10.13422/j.cnki.syfjx.2011.02.040.

摘要

目的:采用体外炎症模型研究瓜子金有效部位群抗炎作用机制。方法:建立脂多糖（LPS）诱导巨噬细胞系RAW264.7细胞体外炎症模型

研究不同浓度瓜子金有效部位群对一氧化氮（NO）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）的释放及对TNF-α和IL-6 mRNA表达的影响。结果:瓜子金有效部位群能显著降低LPS诱导的RAW264.7细胞NO

IL-6及TNF-α的释放

显著降低TNF-α及IL-6 mRNA的表达。结论:瓜子金有效部位群抗炎作用与其减少巨噬细胞炎症介质的生成与释放及降低TNF-α和IL-6 mRNA的表达密切相关。

Abstract

Objective: The inflammatory model in vitro was used to evaluate the anti-inflammatory mechanism of Polygala japonica effective ingredients.Method: RAW264.7 macrophage line was induced by lipopolysaccharide（LPS） to set up the inflammatory model.To study the effect of P.japonica effective ingredients on the inflammation factors by assaying the concentration of nitric oxide（NO）

tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6）.The mRNA expression of TNF-α and IL-6 was assayed with real-time quantitative polymerase chain reaction（PCR） too.Result:P.japonica effective ingredients could significantly reduce the release of NO

IL-6 and TNF-α in LPS-induced RAW264.7 macrophage line

and obviously decrease the mRNA expression of TNF-α and IL-6

too.Conclusion:The anti-inflammatory mechanism of P.japonica effective ingredients may be related to reducing the release of inflammation factors in macrophage cell and inhibiting the mRNA expression of TNF-α and IL-6.

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