Preliminary Study on Effects of Xixin Oil on Blood Histamine and Pathomorphological Change in Nasal Mucosa in Guinea Pigs with Allergic Rhinitis

LIANG Shao-yu; TAN Xiao-mei; ZENG Yong-chang; GAO Jie; WANG Wei-fu; HU Yuan-li

doi:10.13422/j.cnki.syfjx.2011.02.044

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Preliminary Study on Effects of Xixin Oil on Blood Histamine and Pathomorphological Change in Nasal Mucosa in Guinea Pigs with Allergic Rhinitis

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- Preliminary Study on Effects of Xixin Oil on Blood Histamine and Pathomorphological Change in Nasal Mucosa in Guinea Pigs with Allergic Rhinitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 149-151(2011)
- 作者机构：
  
  南方医科大学中医药学院广东省中药制剂重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.044
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]梁少瑜,谭晓梅,曾永长,高婕,王维赋,胡元利.细辛挥发油对过敏性鼻炎豚鼠鼻黏膜和组胺影响的初步研究[J].中国实验方剂学杂志,2011,17(02):149-151.

LIANG Shao-yu, TAN Xiao-mei, ZENG Yong-chang, et al. Preliminary Study on Effects of Xixin Oil on Blood Histamine and Pathomorphological Change in Nasal Mucosa in Guinea Pigs with Allergic Rhinitis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 149-151.
[1]梁少瑜,谭晓梅,曾永长,高婕,王维赋,胡元利.细辛挥发油对过敏性鼻炎豚鼠鼻黏膜和组胺影响的初步研究[J].中国实验方剂学杂志,2011,17(02):149-151. DOI： 10.13422/j.cnki.syfjx.2011.02.044.

LIANG Shao-yu, TAN Xiao-mei, ZENG Yong-chang, et al. Preliminary Study on Effects of Xixin Oil on Blood Histamine and Pathomorphological Change in Nasal Mucosa in Guinea Pigs with Allergic Rhinitis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 149-151. DOI： 10.13422/j.cnki.syfjx.2011.02.044.

摘要

目的:探讨细辛挥发油对过敏性鼻炎（AR）豚鼠行为学指标、鼻黏膜病理形态和血液组胺含量的影响。方法:将FMMU豚鼠40只按体重随机分为生理盐水对照组、AR模型组、辛芩颗粒组、细辛挥发油组

每组10只。采用鸡卵清蛋白全身致敏与局部攻击方法制作AR豚鼠模型

对照组和模型组给予生理盐水

辛芩颗粒组给予辛芩颗粒4.65g·kg-1

细辛挥发油组给予细辛挥发油按生药量计0.45 g·kg-1

观察豚鼠行为学指标和鼻黏膜病理形态的变化

测定血液组胺含量。结果:细辛挥发油组鼻痒、喷嚏、清涕等行为学指标及鼻黏膜炎症程度均有明显改善

血液组胺含量明显降低。结论:细辛挥发油能有效缓解过敏性鼻炎的局部症状

降低血液组胺含量

改善鼻黏膜炎症的局部浸润

达到治疗过敏性鼻炎的目的。

Abstract

Objective:To observe the effect of Xixin oil on blood histamine content and pathomorphological change in nasal mucosa of guinea pigs with allergic rhinitis（AR）.Method:Forty FMMU guinea pigs were randomly divided into control group

AR model group

Xinqin granule group and Xixin oil group

with 10 cases in each group.Generally sensitized guinea pigs were received repeated local sensitization in nasal cavity with ovalbumin.Guinea pigs in control group and model group were given normal saline

while guinea pigs in Xinqin granule group were given 4.65 g.kg-1 Xinqin granule and 0.45 g.kg-1 volatile oil for Xixin oil group.Pathomorphological changes in nasal mucosa were observed and blood histamine was determined for each group.Result: Xixin oil could significantly reduce the amount of nasal secretions

sneezing and the degree of nasal scratching of AR guinea pigs.The degree of nasal mucosal inflammation in Xixin oil group was improved and the content of histamine was decreased obviously.Conclusion:Xixin oil can alleviate local symptoms and improve the degree of inflammation after local invasion in nasal mucosal of guinea pigs with AR.The possible mechanism might be related with inhibition of histamine release

which play an important role in the treatment of allergic rhinitis.

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Related Author

LIANG Shao-yu

TAN Xiao-mei

ZENG Yong-chang

GAO Jie

WANG Wei-fu

HU Yuan-li

LU Bin

WANG Zai-yong

Related Institution

Beijing University of Chinese Medicine

State Key Laboratory of Southwestern Chinese Medicine Resources， Chengdu University of Traditional Chinese Medicine

Basic Medical College， Heilongjiang University of Chinese Medicine

College of Pharmacy， Heilongjiang University of Chinese Medicine

Hubei Research Center of Chinese Materia Medica Processing Engineering and Technology， School of Pharmacy，Hubei University of Chinese Medicine

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