Effect of Zhiwei Fuwei Concentrated Pill on SOD activity,MDA and NO Content in Model Rat with Chronic Atrophic Gastritis

SHU Jin1; LI Xi-xiang1; REN Yuan2; LI Sheng-cai1; WU Guo-tai2; HONG Qiu-ju2

doi:10.13422/j.cnki.syfjx.2011.02.046

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Effect of Zhiwei Fuwei Concentrated Pill on SOD activity,MDA and NO Content in Model Rat with Chronic Atrophic Gastritis

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- Effect of Zhiwei Fuwei Concentrated Pill on SOD activity,MDA and NO Content in Model Rat with Chronic Atrophic Gastritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 160-162(2011)
- 作者机构：
  
  1. 甘肃省中医院
  2. 甘肃中医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.046
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]舒劲,李喜香,任远,李生财,吴国泰,洪秋菊.制萎扶胃浓缩丸对慢性萎缩性胃炎模型大鼠SOD活性、MDA和NO含量的影响[J].中国实验方剂学杂志,2011,17(02):160-162.

SHU Jin1, LI Xi-xiang1, REN Yuan2, et al. Effect of Zhiwei Fuwei Concentrated Pill on SOD activity,MDA and NO Content in Model Rat with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 160-162.
[1]舒劲,李喜香,任远,李生财,吴国泰,洪秋菊.制萎扶胃浓缩丸对慢性萎缩性胃炎模型大鼠SOD活性、MDA和NO含量的影响[J].中国实验方剂学杂志,2011,17(02):160-162. DOI： 10.13422/j.cnki.syfjx.2011.02.046.

SHU Jin1, LI Xi-xiang1, REN Yuan2, et al. Effect of Zhiwei Fuwei Concentrated Pill on SOD activity,MDA and NO Content in Model Rat with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 160-162. DOI： 10.13422/j.cnki.syfjx.2011.02.046.

摘要

目的:观察制萎扶胃浓缩丸对慢性萎缩性胃炎（CAG）模型大鼠血清超氧化物歧化酶（SOD）活性、丙二醛（MDA）和一氧化氮（NO）含量的影响

探讨其防治慢性萎缩性胃炎的作用机制。方法:采用综合因素（30%乙醇与2%水杨酸钠混合液与10 mmol·L-1去氧胆酸钠交替ig

0.05%氨水日常饮用

结合主动免疫法

并令其饥饱失常）诱发大鼠建立实验性慢性萎缩性胃炎模型

ig制萎扶胃浓缩丸（FW）高、中、低剂量（分别为1.67

0.84

0.42 g·kg-1）75 d后测定血清和胃黏膜SOD活性和MDA

NO含量。结果:制萎扶胃浓缩丸高、低剂量明显增高CAG模型大鼠血清SOD活性（P<0.01）

高剂量明显增高CAG模型大鼠胃黏膜SOD活性;各剂量均能降低CAG模型大鼠血清和胃黏膜MDA含量（P<0.01

或P<0.05）;高、中剂量能升高CAG模型大鼠胃黏膜NO含量（P<0.05）

各剂量对血清NO含量有降低的趋势。结论:制萎扶胃浓缩丸能改变CAG模型大鼠胃黏膜组织和血液的SOD活性和MDA

NO含量

使其趋于正常水平

通过抗氧化、清除自由基作用有效防治慢性萎缩性胃炎。

Abstract

Objective: To observe the effect of Zhiwei Fuwei concentrated pill（FW） for superoxide dismutase（SOD） activity

malondialdehyde（MDA） and nitric oxide（NO） content in model rats

of chronic atrophic gastritis（CAG）

and to investigate the mechanism of FW in prevention and treatment of CAG.Method: An experimental CAG model was established by comprehensive factors

including using alternative ingestion with 30% ethanol and 2% sodium salicylate mixed solution and 10 mmol·L-1 sodium deoxycholate

drinking of 0.05% ammonia daily

combining with active immunization

followed by either hunger or gorge in wistar rats.The SOD activity and MDA content in serum and gastric mucosa were determined after 75 days of FW treatment（1.67

0.84

0.42 g·kg-1）.Result:The high and low dosage of FW could promote SOD activity in serum significantly（P < 0.01）.The high dosage could promote SOD activity in gastric mucosa.The FW could reduce MDA content

and increase NO content in gastric mucosa.Conclusion:FW can make SOD activity

MDA and NO content tend to be normal by antioxidating and scavenging free radicals to prevent and treat CAG effectively.

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SHU Jin

LI Xi-xiang

REN Yuan

LI Sheng-cai

WU Guo-tai

HONG Qiu-ju

LIU Chun-fang1

LIN Na1

Related Institution

中国中医科学院骨伤科研究所

1),CHEN Wei-heng~2,WAN Rong~1,WANG Yan-wei~1,QIAO Li~1

Guangdong Second Prowincial Traditional Chinese Medicine Hospital

First People’s Hospital of Shunde District

The R&D Center of Drug for Renal Diseases,Guangzhou Consun Pharmaceutical Co.,Ltd

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