Effects of Huanglian Jiedu Decoction on Blood Lipid and Oxygen Radical Metabolism in Experimental Hyperlipidemia Rats

ZHANG Yang1; JIN Jin1; ZHANG Lian-zhu1; LIN Yong2; HU Wen-xiang3; XU Nan-nan3; ZHOU Qiu-li1

doi:10.13422/j.cnki.syfjx.2011.02.049

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Effects of Huanglian Jiedu Decoction on Blood Lipid and Oxygen Radical Metabolism in Experimental Hyperlipidemia Rats

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- Effects of Huanglian Jiedu Decoction on Blood Lipid and Oxygen Radical Metabolism in Experimental Hyperlipidemia Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 169-172(2011)
- 作者机构：
  
  1. 吉林大学药学院
  2. 长春市中心医院
  3. 首都师范大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.049
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]张扬,金瑾,张莲珠,蔺勇,胡文祥,徐楠楠,周秋丽.黄连解毒汤对高脂血症大鼠血脂及氧自由基代谢的影响[J].中国实验方剂学杂志,2011,17(02):169-172.

ZHANG Yang1, JIN Jin1, ZHANG Lian-zhu1, et al. Effects of Huanglian Jiedu Decoction on Blood Lipid and Oxygen Radical Metabolism in Experimental Hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 169-172.
[1]张扬,金瑾,张莲珠,蔺勇,胡文祥,徐楠楠,周秋丽.黄连解毒汤对高脂血症大鼠血脂及氧自由基代谢的影响[J].中国实验方剂学杂志,2011,17(02):169-172. DOI： 10.13422/j.cnki.syfjx.2011.02.049.

ZHANG Yang1, JIN Jin1, ZHANG Lian-zhu1, et al. Effects of Huanglian Jiedu Decoction on Blood Lipid and Oxygen Radical Metabolism in Experimental Hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 169-172. DOI： 10.13422/j.cnki.syfjx.2011.02.049.

摘要

目的:探讨黄连解毒汤（Huanglian Jiedu Decoction

HJD）对实验性高脂血症大鼠血脂及氧自由基代谢的影响。方法:将50只SD大鼠随机分为正常对照组

模型组

立普妥组（0.2 mg·kg-1）

HJD低、高剂量组（6

12 g·kg-1）。除正常对照组外

其他组大鼠喂饲高脂饲料建立高脂血症模型。连续ig 8周后

测定血清总胆固醇（total cholesterol

TC）、三酰甘油（triacylglycerol

TAG）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol

LDL-C）和高密度脂蛋白胆固醇（high-densitylipoprotein cholesterol

HDL-C）水平

以及超氧化物歧化酶（superoxide dismutase

SOD）和谷胱甘肽过氧化酶（glutathioneperoxidase

GSH-Px）活性及丙二醛（malondialdehyde

MDA）含量

并观察肝组织病理学改变。结果:与模型组比较

HJD各组能明显降低实验大鼠血清TC

LDL-C

MDA含量

显著提高HDL-C含量和SOD

GSH-Px活性

并能减轻肝细胞脂肪变性。结论:HJD能有效调节高脂血症大鼠血脂代谢

提高机体抗氧化能力

改善肝组织病理损害。

Abstract

Objective:To study the effects of Huanglian Jiedu Decoction（HJD） on blood lipid and oxygen radical metabolism in experimental hyperlipidemia rats.Method: Fifty SD rats were randomly divided into normal control group

untreated group

lipitor group（0.2 mg·kg-1）

and low-and high-dose HJD group（6

12 g·kg-1）.Except the normal control group

rats in the other groups were fed with high fat diet for 15 days to induce hyperlipidemia.Then the rats were administered with corresponding drugs for 8 weeks.After treatment

the serum levels of total cholesterol（TC）

triacylglycerol（TAG）

low-density lipoprotein cholesterol（LDL-C） and high-density lipoprotein cholesterol（HDL-C） were assayed.The activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） and the level of malondialdehyde（MDA） were measured.The histological changes in liver tissues were observed.Result: Compared with the untreated group

HJD could significantly decrease the serum levels of TC

LDL-C and MDA

increase the serum level of HDL-C and the activities ofSOD and GSH-Px

and relieve the fatty degeneration of hepatic cells.Conclusion: HJD has the potential effect to regulate the lipid metabolism of hyperlipidemia rats

increase antioxidant activity and improve the histopathological injury of the liver.

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HU Wen-xiang

XU Nan-nan

ZHOU Qiu-li

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Related Institution

Chengdu University of TCM

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

Hospital of Chengdu University of TCM

Chengdu University of Traditional Chinese Medicine（TCM）

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory/Jiangxi Province Key Laboratory of Biological Etiologies of TCM/First-Level Discipline Platform of Chinese and Western Integrative Medicine/Experimental Animal and Scientific Technology Center of Jiangxi University of Chinese Medicine/School of Pharmacy， Jiangxi University of Chinese Medicine

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