Influence of Qinxiang Granules on Small Intestinal Mucosal Lymphocytes in Suckling Mice with HRV Infection

WANG Li1; PENG Zhi-pei1; TENG Jiu-xiang2; WU Shen-rong2; ZHANG Guo-min2; YIN Jian2; TANG Xi2

doi:10.13422/j.cnki.syfjx.2011.02.050

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Influence of Qinxiang Granules on Small Intestinal Mucosal Lymphocytes in Suckling Mice with HRV Infection

更新时间：2024-09-23

- Influence of Qinxiang Granules on Small Intestinal Mucosal Lymphocytes in Suckling Mice with HRV Infection
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 173-176(2011)
- 作者机构：
  
  1. 湖南中医药大学第二附属医院
  2. 湖南中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.050
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]王丽,彭芝配,滕久祥,伍参荣,张国民,殷坚,唐曦.秦香颗粒对人轮状病毒(HRV)感染乳鼠小肠黏膜淋巴细胞的影响[J].中国实验方剂学杂志,2011,17(02):173-176.

WANG Li1, PENG Zhi-pei1, TENG Jiu-xiang2, et al. Influence of Qinxiang Granules on Small Intestinal Mucosal Lymphocytes in Suckling Mice with HRV Infection[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 173-176.
[1]王丽,彭芝配,滕久祥,伍参荣,张国民,殷坚,唐曦.秦香颗粒对人轮状病毒(HRV)感染乳鼠小肠黏膜淋巴细胞的影响[J].中国实验方剂学杂志,2011,17(02):173-176. DOI： 10.13422/j.cnki.syfjx.2011.02.050.

WANG Li1, PENG Zhi-pei1, TENG Jiu-xiang2, et al. Influence of Qinxiang Granules on Small Intestinal Mucosal Lymphocytes in Suckling Mice with HRV Infection[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 173-176. DOI： 10.13422/j.cnki.syfjx.2011.02.050.

摘要

目的:观察秦香颗粒（秦香）对HRV感染乳鼠小肠黏膜淋巴细胞的影响

探讨秦香颗粒治疗人轮状病毒（HRV）感染性腹泻的可能作用机制。方法:将乳鼠随机分成7组

正常组常规饲养

其余6组造成HRV感染模型

并分别ig生理盐水、秦香颗粒高、中、低剂量（1.44

0.72

0.36 g·kg-1）、病毒唑（0.11 g·kg-1·d-1）及肠康片（0.52 g·kg-1·d-1）

连续给药5 d。采用金标法检测粪便HRV抗原

免疫组化法观察小肠黏膜淋巴细胞的变化。结果:与正常组比较

各治疗组及模型组小肠黏膜淋巴细胞CD4+减少（P<0.05）;与模型组比较

各给药组小肠黏膜淋巴细胞CD4+的数量不同程度上升

其中秦香颗粒高、中剂量组及病毒唑组具有统计学意义（P<0.05）;与正常对照组比较

各给药组及模型组小肠黏膜淋巴细胞CD8+数量不同程度增加

与模型组比较

各组小肠黏膜淋巴细胞CD8+的数量不同程度减少

差异均具有统计学意义（P<0.05）。结论:秦香颗粒可以上调HRV感染乳鼠小肠黏膜CD4+、下调CD8+

有利于增强淋巴细胞对肠黏膜的保护作用

减轻肠黏膜病变

对HRV感染性腹泻有一定的治疗作用。

Abstract

Objective:To observe Qinxiang granules（Qinxiang Zhixie tablets） influence on small intestinal mucosa lymphocytes in suckling mice with HRV infection.Method:The suckling mice were randomly divided into 7 groups

the normal control group

the other six groups as the model of HRV infection.The normal control group was treated with NS

and the other experimented groups differently treated with Qinxiang granules（High dose/medium dose/low dose

1.44/0.72/0.36 g·kg-1）

ribavirin（0.11 g·kg-1）

Changkang tablets（0.52 g·kg-1） for 5 days.The changes in small intestinal was observed.Result:Compared with the normal control group

in each treatment group and model group reduction of small intestinal CD4+lymphocytes was statistically significant（P<0.05）.Compared with model group

in the treatment groups small intestinal CD4+lymphocytes were increased in high

medium dose groups and ribavirin group the increase was significant（P<0.05）;comparied with normal control group

in each treatment group and model group

the number of small intestinal CD8+lymphocytes was increased to various degree.Compared with model group

in the treatment groups small intestinal CD8+lymphocytes werereduced

and the differences were significant（P<0.05）.Conclusion: Qinxiang granules can increase small intestinal CD4+

lower CD8+in suckling mice.The Qinxiang granules is conducive for enhancing the protection of the intestinal mucosa with lymphocytes

and reducing mucosal lesions.

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