α-Glucosidase Inhibitory and Antioxidant Activities of Polygonum perfoliatum

XING Yu-jun; WANG Hai-yan; WANG Jun-xia; LI Yuan-yuan; KANG Wen-yi

doi:10.13422/j.cnki.syfjx.2011.02.053

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α-Glucosidase Inhibitory and Antioxidant Activities of Polygonum perfoliatum

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- α-Glucosidase Inhibitory and Antioxidant Activities of Polygonum perfoliatum
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 189-191(2011)
- 作者机构：
  
  河南大学中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.053
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]邢煜君,王海燕,王俊霞,李园园,康文艺.杠板归抗氧化作用及抑制α-葡萄糖苷酶活性[J].中国实验方剂学杂志,2011,17(02):189-191.

XING Yu-jun, WANG Hai-yan, WANG Jun-xia, et al. α-Glucosidase Inhibitory and Antioxidant Activities of Polygonum perfoliatum[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 189-191.
[1]邢煜君,王海燕,王俊霞,李园园,康文艺.杠板归抗氧化作用及抑制α-葡萄糖苷酶活性[J].中国实验方剂学杂志,2011,17(02):189-191. DOI： 10.13422/j.cnki.syfjx.2011.02.053.

XING Yu-jun, WANG Hai-yan, WANG Jun-xia, et al. α-Glucosidase Inhibitory and Antioxidant Activities of Polygonum perfoliatum[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 189-191. DOI： 10.13422/j.cnki.syfjx.2011.02.053.

摘要

目的:考察杠板归抗氧化及抑制α-葡萄糖苷酶活性作用。方法:通过对ABTS自由基和DPPH自由基的清除能力及FRAP法对杠板归的抗氧化活性进行评价。应用体外α-葡萄糖苷酶筛选模型进行杠板归酶抑制活力的测定。结果:杠板归乙酸乙酯和甲醇提取物具有一定的抗氧化活性

其中甲醇提取物抗氧化活性最好

在ABTS、DPPH和FRAP方法中的Trolox当量分别为701.60±25.35

338.66±11.26

392.52±12.89μmolTE·g-1。杠板归3种提取物均具有很好的抑制α-葡萄糖苷酶活性作用

其中甲醇提取物活性最好

IC50值为16.14 mg·L-1。结论:杠板归甲醇提取物的抗氧化和抑制α-葡萄糖苷酶活性均最好

推测其可以用于糖尿病的治疗。

Abstract

Objective:To investigate the antioxidant and α-glucosidase inhibitory activities of Polygonum perfoliatum L.Method: The total antioxidant capacity was determined by using the [2

2′-azino-bis-3-ethylbenzothizaoline-6-sulfonic acid]diammonium salt（ABTS） radical scavenging

1-diphenyl-2-picryl-2-picryl-hydrazyl（DPPH） radical scavenging and ferric reducing antioxidant power（FRAP） assay and α-glucosidase inhibitory activity was determined by external screening model.Result:The ethyl acetate and methanol extracts of P.perfoliatum L.had antioxidant activity

and the methanol extract had the best activity;the Trolox equivalents in ABTS

DPPH and FRAP methods were 701.60±25.35

338.66±11.26

392.52±12.89 μmolTE·g-1 respectively.Three extracts of P.perfoliatum L.had good α-glucosidase inhibitory activity

and the methanol extract was the best

which IC50 value was 16.14 mg.L-1.Conclusion:The methanol extract had the best antioxidant and α-glucosidase inhibitory activities

speculated it would be used for the treatment of diabetes.

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