Comparative Studies on Acute Toxicity of Cinnabar,Zhusha Anshenwan,Mercuric Chloride and Mercurous Chloride

HE Han-yang1; KANG Feng1; YAN Jun-wen2; LIU Jie2; SHI Jing-zhen1

doi:10.13422/j.cnki.syfjx.2011.02.060

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Comparative Studies on Acute Toxicity of Cinnabar,Zhusha Anshenwan,Mercuric Chloride and Mercurous Chloride

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- Comparative Studies on Acute Toxicity of Cinnabar,Zhusha Anshenwan,Mercuric Chloride and Mercurous Chloride
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 219-223(2011)
- 作者机构：
  
  1. 贵阳中医学院实验中心基础医学实验室
  2. 遵义医学院药理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.060
  CLC： R285
- Published：2011
- 稿件说明：
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[1]何海洋,康峰,颜俊文,刘杰,时京珍.朱砂、朱砂安神丸与氯化汞、轻粉的急性毒性对比[J].中国实验方剂学杂志,2011,17(02):219-223.

HE Han-yang1, KANG Feng1, YAN Jun-wen2, et al. Comparative Studies on Acute Toxicity of Cinnabar,Zhusha Anshenwan,Mercuric Chloride and Mercurous Chloride[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 219-223.
[1]何海洋,康峰,颜俊文,刘杰,时京珍.朱砂、朱砂安神丸与氯化汞、轻粉的急性毒性对比[J].中国实验方剂学杂志,2011,17(02):219-223. DOI： 10.13422/j.cnki.syfjx.2011.02.060.

HE Han-yang1, KANG Feng1, YAN Jun-wen2, et al. Comparative Studies on Acute Toxicity of Cinnabar,Zhusha Anshenwan,Mercuric Chloride and Mercurous Chloride[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 219-223. DOI： 10.13422/j.cnki.syfjx.2011.02.060.

摘要

目的:对比研究朱砂、朱砂安神丸与氯化汞、轻粉对小鼠的急性毒性。方法:小鼠一次给药后

分别检测肝肾组织中汞蓄积量

肝肾功能

观察肝、肾、等主要脏器的组织形态学变化

并运用实时荧光定量PCR（RT-PCR）的方法检测药物对MT-1

MT-2基因表达的影响。结果:氯化汞组小鼠肝、肾组织中汞蓄积量（13.2±7.63）

（46.9±20.4）mg·kg-1远远高于朱砂低剂量组（0.18±0.35）

（0.50±0.57）mg·kg-1

朱砂高剂量组（3.80±1.65）

（23.9±9.95）mg·kg-1和朱砂安神丸低剂量组（0.22±0.23）

（0.67±0.43）mg·kg-1

朱砂安神丸高剂量组（0.31±0.32）

（0.72±0.57）mg·kg-1以及轻粉组（0.39±0.20）

（0.76±0.48）mg·kg-1;朱砂高剂量组肝（863±469）

（1 057±690）、肾（603±30）

（3 114±313）、氯化汞组肝（1 385±364）

（2 284±701）、肾（621±186）

（3 162±493）组织中MT-1和MT-2 mRNA表达高于其他各组;朱砂高剂量组和氯化汞组小鼠肝肾组织中出现病理损伤。结论:小鼠一次性给药后

临床常用量的朱砂和朱砂安神丸毒性要远远小于氯化汞。

Abstract

Objective:To study the acute toxicity of cinnabar

Zhusha Anshenwan

mercuric chloride and mercurous chloride in mouse.Method: Mouse were orally given Zhusha Anshenwan（10

20 g.kg-1）

cinnabar（0.3

16 g·kg-1）

mercuric chloride（70 mg·kg-1） and mercurous chloride（61.2 mg.kg-1）

and toxicity were assayed 8 hours later.Result:Compared with the normal group

the renal injury occurred in mercuric chloride group;The accumulation of mercury in mercuric chloride group was much higher than other groups;mercuric chloride and the high dose of cinnabar can cause liver and kidney pathological changes

The RT-PCR analysis indicated that the expression of MT-1 and MT-2 increased in mercuric chloride groups and the high dose of cinnabar

In Zhusha Anshenwan

low dose of cinnabar and mercurous chloride groups

tissue Hg accumulation was insignificant and No MT induction was abserved.Conclusion:Acute toxicity of cinnabar and Zhusha Anshenwan at clinical dosages is much lower than that of mercuric chloride.

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SHI Jing-zhen

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Related Institution

Guangxi Scientific Experimental Center of TCM, Guangxi University of Chinese Medicine

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School of Pharmacy, Guangxi University of Chinese Medicine

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Guangxi Key Laboratory for Pharmacodynamics Research of Traditional Chinese Medicine(TCM)

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