Reactive Essence between Chinese Materia Medica Formula and Human Body:Multiple Genetic Chromatodynamokinetics with ‘Co-network Compatibility and Rainbow Potential’

HE Fu-yuan1; DENG Kai-wen4; LIU Weng-long1; 2 SHI Ji-lian1; ZOU Huan1; TANG Yu2; LIU Ping-an2; ZHOU Hong-hao5

doi:10.13422/j.cnki.syfjx.2011.02.062

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Reactive Essence between Chinese Materia Medica Formula and Human Body:Multiple Genetic Chromatodynamokinetics with ‘Co-network Compatibility and Rainbow Potential’

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- Reactive Essence between Chinese Materia Medica Formula and Human Body:Multiple Genetic Chromatodynamokinetics with ‘Co-network Compatibility and Rainbow Potential’
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 2, Pages: 240-247(2011)
- 作者机构：
  
  1. 湖南中医药大学药学院
  2. 中药药性与药效国家中医药管理局重点实验室
  3. 湖南中医药大学现代中药制剂技术与评价实验室
  4. 中南大学临床药理研究所
  5. 湖南中医药大学第一附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.02.062
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]贺福元,邓凯文,刘文龙,石继连,邹欢,唐宇,刘平安,周宏灏.中药复方对人体作用本质:“网通虹势”的多重遗传谱效动力学[J].中国实验方剂学杂志,2011,17(02):240-247.

HE Fu-yuan1, DENG Kai-wen4, LIU Weng-long1, et al. Reactive Essence between Chinese Materia Medica Formula and Human Body:Multiple Genetic Chromatodynamokinetics with ‘Co-network Compatibility and Rainbow Potential’[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 240-247.
[1]贺福元,邓凯文,刘文龙,石继连,邹欢,唐宇,刘平安,周宏灏.中药复方对人体作用本质:“网通虹势”的多重遗传谱效动力学[J].中国实验方剂学杂志,2011,17(02):240-247. DOI： 10.13422/j.cnki.syfjx.2011.02.062.

HE Fu-yuan1, DENG Kai-wen4, LIU Weng-long1, et al. Reactive Essence between Chinese Materia Medica Formula and Human Body:Multiple Genetic Chromatodynamokinetics with ‘Co-network Compatibility and Rainbow Potential’[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 240-247. DOI： 10.13422/j.cnki.syfjx.2011.02.062.

摘要

目的:从学科的属性与特点探讨中药复方对人体作用本质:"网通虹势"多重遗传谱效动力学。分析中药学科与遗传药理学科研究的特点

根据中药复方药效物质作用的本源

结合中药现代化的要求

提出中药现代化的思路与方法。结果:与西药相比

中药复方为具有自然界原生物体遗传信息的多成分有机整体

在以初生、次生代谢酶系

特别是细胞色素P-450（CYP450）家族酶的作用下合成

进入人体内能被人体以CYP450家族酶为主的酶系按"网通虹势"规律代谢

并与人体内的初生代谢酶系（受体）按质量作用定律产生"反治互补"的药理效应

体现多重遗传谱效动力学特点。结论:中药复方与人体的药效本质是生物体间多重遗传药理学作用

体现"网通虹势"谱效动力学特征

是自然界生物体之间普遍遵循的作用规律

可用遗传多态性的规律来进行研究。

Abstract

Objective: To deal with the reactive essence between the Chinese materia medica（CMM） formula and human body: multiple genetic chromatodynamokinetics（pharmacodynamics with chromatographic fingerprint）

with‘Co-network compatibility and rainbow potential’according to properties and characteristics of disciplines.Method:The research characteristics of pharmacogenetics and pharmacy of CMM formula was analyzed

according to the effective mechanism of constitutes in CMM formula

combined with the requirements of modernization of CMM

to illuminate the modernization thoughts and methods of CMM.Result:The CMM formula

compared with west medicine

is an integer with multiple-constitutes carrying with original biologic genetic polymorphic information

synthesized out under primary and secondary metabolic enzymes

especially cytochrome P-450（CYP450） enzymes

imported into human body and metabolized by CYP450 enzymes

on metabolic actions with ‘co-network compatibility and rainbow potential’regularity

to show effects at end with receptors

similar to metabolic enzymes in primary channels of human being

with‘counter-treatment and complementation’reactions of multiple genetic chromatodynamokinetic by mass law.Conclusion:Conclusion:The pharmacodynamics essence between CMM formula and human body is multiple genetic chromatodynamokinetics among biology

abided by nature biology as common regularity

studied with biologic polymorphic methods.

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Related Author

HE Fu-yuan

DENG Kai-wen

LIU Weng-long

SHI Ji-lian

ZOU Huan

TANG Yu

LIU Ping-an

ZHOU Hong-hao

Related Institution

Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique， Ministry of Education，State Key Laboratory of Component-based Chinese Medicine，Haihe Laboratory of Modern Chinese Medicine，Tianjin University of Traditional Chinese Medicine

School of Pharmacy，School of Basic Medical Sciences， Chengdu University of Traditional Chinese Medicine

Tianjin Modern Innovation TCM Technology Co. Ltd.

College of Pharmaceutical Engineering of Traditional Chinese Medicine （TCM）， Tianjin University of TCM

The First Hospital of Hunan University of Chinese Medicine

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