Study on Stability and Solubilization of Amomum volatile Oil Hydroxypropyl-β-cyclodextrin Inclusion Complex

ZHANG Sheng-tan; WANG Tie-shan; LIN Jing-ming

doi:10.13422/j.cnki.syfjx.2011.04.022

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Study on Stability and Solubilization of Amomum volatile Oil Hydroxypropyl-β-cyclodextrin Inclusion Complex

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- Study on Stability and Solubilization of Amomum volatile Oil Hydroxypropyl-β-cyclodextrin Inclusion Complex
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 4, Pages: 53-56(2011)
- 作者机构：
  
  南方医科大学珠江医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.04.022
  CLC： R283.6
- Published：2011
- 稿件说明：
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[1]张生潭,汪铁山,林敬明.春砂仁挥发油羟丙基-β-环糊精包合物的稳定性及增溶作用研究[J].中国实验方剂学杂志,2011,17(04):53-56.

ZHANG Sheng-tan, WANG Tie-shan, LIN Jing-ming. Study on Stability and Solubilization of Amomum volatile Oil Hydroxypropyl-β-cyclodextrin Inclusion Complex[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 53-56.
[1]张生潭,汪铁山,林敬明.春砂仁挥发油羟丙基-β-环糊精包合物的稳定性及增溶作用研究[J].中国实验方剂学杂志,2011,17(04):53-56. DOI： 10.13422/j.cnki.syfjx.2011.04.022.

ZHANG Sheng-tan, WANG Tie-shan, LIN Jing-ming. Study on Stability and Solubilization of Amomum volatile Oil Hydroxypropyl-β-cyclodextrin Inclusion Complex[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 53-56. DOI： 10.13422/j.cnki.syfjx.2011.04.022.

摘要

目的:考察砂仁挥发油包合物的稳定性及羟丙基-β-环糊精对挥发油的增溶作用。方法:以乙酸龙脑酯和樟脑的为考察指标

采用HPLC测定包合物及物理混合物中乙酸龙脑酯及樟脑的含量

在高温高湿及强光照的条件下进行试验

并采用相溶解度法测定羟丙基-β-环糊精对挥发油的增溶作用。结果:在高温高湿及强光照条件下

包合物中乙酸龙脑酯及樟脑的含量均明显高于物理混合物中的两种成分的含量

增溶试验显示羟丙基-β-环糊精在50%浓度下可提高挥发油的溶解度约35倍。结论:包合物抗高温、高湿、强光照较物理混合物强

且羟丙基-β-环糊精可明显增加砂仁挥发油的溶解度。

Abstract

Objective:To investigate the stability of volatile oil inclusion from Amomum and solubilization of volatile oil by hydroxypropyl-β-cyclodextrin.Method:The content of bornyl acetate and camphor in inclusion com-plex and physical mixture under the high temperature

humidity and strong light conditions was determined by HPLC with bornyl acetate and camphor as index and the solubilization of the volatile oil by hydroxypropyl-β-cyclodextrin was determined by phase solubility method.Result:Under the high temperature

humidity and strong light condi-tions

the content of bornyl acetate and camphor in inclusion was higher than that of in physical mixture

the results of solubility test showed that 50% concentration of hydroxypropyl-β-cyclodextrin could increase the solubility of es-sential oil of about 35 times.Conclusion:The inclusion complex had higher capability on anti high temperature

high humidity and strong light intensity than the physical mixture

and the hydroxypropyl-β-cyclodextrin could increase the solubility of essential oil significantly.

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Related Author

ZHANG Sheng-tan

WANG Tie-shan

LIN Jing-ming

LUO Yi

LIU Wen

DENG Nan

DAI Ying-chun

JIANG Yan-yan

Related Institution

School of Chinese Pharmacy,Beijing University of Chinese Medicine

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

School of TCM，Capital Medical University

School of Pharmacy，Nanjing University of Chinese Medicine

Jiangsu Institute for Food and Drug Control

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