DENG Hang1, HE Min1, LI Jiang1, et al. Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 114-117.
DENG Hang1, HE Min1, LI Jiang1, et al. Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 114-117. DOI: 10.13422/j.cnki.syfjx.2011.04.040.
Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin
Objective:To investigate the hypoglycemic effect and its action mechanism of persimmon leaf polysaccharide in diabetic mice induced by streptozotocin(STZ).Method:The diabetic mice were induced by STZ.Mice were randomly divided into 5 groups:control group
model group
glibenclamide group(25 mg·kg-1·d-1)
low and high dose groups of persimmon leaf polysaccharide(150 mg·kg-1·d-1
600 mg·kg-1·d-1).The drugswere administrated to mice in every morning for 15 days.In the corresponding time
the contents of fasting blood glu-cose(FBG)
fasting insulin(FINS)
malondialdehyde(MDA)
superoide dismutase(SOD)activity
insulin sensi-tivity index(ISI)and oral glucose tolerance test(OGTT)were determined.Result:The persimmon leaf polysaccha-ride could markedly decrease blood glucose in STZ-induced diabetic mice.Meanwhile it could reduce the content ofMDA and increase the activity of SOD in liver
and increase insulin sensitivity index(ISI)and the amount of isletcells.Conclusion:The persimmon leaf polysaccharide decreases blood glucose
and it has a very potential value inthe treatment of diabetes.
Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin
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Related Author
DENG Hang
HE Min
LI Jiang
LUO Xu-yan
HUNG Ren-bin
YUAN Yue
GAO Yunxiao
ZHANG Qiuyan
Related Institution
Institute of Basic Medical Sciences,Beijing Key Laboratory of Chinese Materia Pharmacology, National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases, Xiyuan Hospital,China Academy of Chinese Medical Sciences
People’ Hospital of Wuxuan,Wuxuan
No.454 Hospital of People’s Liberation Army
Chinese Medical Department of Hebei Union University