Effects and Its Mechanism of Evodia lepta on Anti-inflammation and Abirritation

DENG Qi; HUANG Mei-jing; GUO Li-bing; HU Xu-guang

doi:10.13422/j.cnki.syfjx.2011.04.043

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Effects and Its Mechanism of Evodia lepta on Anti-inflammation and Abirritation

更新时间：2024-09-23

- Effects and Its Mechanism of Evodia lepta on Anti-inflammation and Abirritation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 4, Pages: 125-128(2011)
- 作者机构：
  
  广东药学院中药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.04.043
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]邓琪,黄美景,郭丽冰,胡旭光.三丫苦抗炎镇痛作用及机制研究[J].中国实验方剂学杂志,2011,17(04):125-128.

DENG Qi, HUANG Mei-jing, GUO Li-bing, et al. Effects and Its Mechanism of Evodia lepta on Anti-inflammation and Abirritation[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 125-128.
[1]邓琪,黄美景,郭丽冰,胡旭光.三丫苦抗炎镇痛作用及机制研究[J].中国实验方剂学杂志,2011,17(04):125-128. DOI： 10.13422/j.cnki.syfjx.2011.04.043.

DENG Qi, HUANG Mei-jing, GUO Li-bing, et al. Effects and Its Mechanism of Evodia lepta on Anti-inflammation and Abirritation[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 125-128. DOI： 10.13422/j.cnki.syfjx.2011.04.043.

摘要

目的:研究三丫苦不同提取物的抗炎镇痛作用并探寻其时效关系及部分机制。方法:通过二甲苯致小鼠耳肿胀、热板法观察小鼠痛阈值、醋酸致小鼠扭体、角叉菜胶诱导小鼠足爪肿胀观察三丫苦不同提取物的抗炎镇痛作用;采用紫外分光光度法和酶联免疫吸附法分别检测炎性组织中前列腺素E2（PGE2

prostaglandin E2）和血清中环氧化酶-2（cyclooxygenase

COX-2）含量。结果:三丫苦茎水提物、根醇提物对二甲苯诱导的小鼠耳肿胀、醋酸致小鼠扭体、角叉菜胶诱导小鼠足爪肿胀具有抑制作用

对炎性组织中PGE2和血清中COX-2含量也有一定的降低作用。结论:三丫苦有较强的抗炎作用

抗炎机制与抑制PGE2生成及COX-2含量有关。

Abstract

Objective:To investigate the anti-inflammatory and pain-relieving effect and mechanism of three extractives of Evodia lepta（Spr.） Merr.Method:The pain models were induced by acetic acid

the hot-plate tests

the Swelling auricles caused by Xylol and swelling paws induced by dextran in mice were used to observe the pain-relieving and anti-inflammatory effects

the spectrophotometric and fluorometric method and The enzyme linked im-muno sorbent assay were used separately to measure prostaglandin E2（PGE2） in inflammatory tissue and cyclooxyge-nase-2（COX-2） in serum.Result:There was significant difference between four types of models and the negative control group in 2 extractives of E.lepta.Conclusion:E.lepta has effect of anti-inflammation and analgesia.The an-ti-inflammation function may be related to its suppression of and PGE2

COX-2.

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