REN Xin-ci1, XU Xian-xiang1, XU Du-juan1, et al. Effects of Achyranthes bidentata Saponins on Bone Metabolism of Osteoporotis Rats Induced by Retioic Acid[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 128-130.
REN Xin-ci1, XU Xian-xiang1, XU Du-juan1, et al. Effects of Achyranthes bidentata Saponins on Bone Metabolism of Osteoporotis Rats Induced by Retioic Acid[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 128-130. DOI: 10.13422/j.cnki.syfjx.2011.04.044.
Effects of Achyranthes bidentata Saponins on Bone Metabolism of Osteoporotis Rats Induced by Retioic Acid
摘要
目的:研究牛膝总皂苷对维甲酸致骨质疏松大鼠骨代谢指标的影响。方法:用维甲酸复制大鼠骨质疏松症模型
给于牛膝总皂苷30
100
300 mg.kg-1连续灌服
测定大鼠血清钙、磷含量
碱性磷酸酶活性、骨钙素含量以及尿液中羟脯氨酸含量
与模型组进行比较。结果:牛膝总皂苷可升高骨质疏松大鼠血钙含量
升高碱性磷酸酶活性和血清骨钙素水平
降低尿中羟脯氨酸水平。结论:牛膝总皂苷可改善骨质疏松大鼠的骨代谢。
Abstract
Objective:To explore effects of Achyranthes bidentata saponins(ABS) on bone metabolism of rats with osteoporotis induced by retioic acid.Method:ABS was given to rats with osteoporosis induced by retioic acid
at doses of 30
100
300 mg.kg-1.Calcium(Ca)
phosphorus(P)
alkaline phosphatase(ALP)
bone gla protein(BGP) and hydroxyproline(HOP) were measured and compared with those of model group.Result:ABS could increase levels of Ca and BGP
enhance ALP activity and decrease HOP level.Conclusion: ABS showed effects on improving bone metabolism of osteoporosis induced by retioic acid in rats.