GONG Cai-xia, WANG Xu-pu, GAO Yan-feng, et al. Renal Protective Effects of Qidan Yishen Jiangtang Capsule on Diabetic Nephropathy in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 140-143.
GONG Cai-xia, WANG Xu-pu, GAO Yan-feng, et al. Renal Protective Effects of Qidan Yishen Jiangtang Capsule on Diabetic Nephropathy in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 140-143. DOI: 10.13422/j.cnki.syfjx.2011.04.048.
Renal Protective Effects of Qidan Yishen Jiangtang Capsule on Diabetic Nephropathy in Rats
Objective:To study the renal protective effects of Qidan Yishen Jiangtang Capsule(QYJC)in diabetic nephropathy rats.Method:The DN rats model was established by one side nephrectomy and intraperitoneal injection of streptozotocin.Then rats were randomly divided into 3 groups: sham-operation group
model group
QYJC group
10 in each group.Rats were given the relevant drugs respectively for 12 weeks.Finally the levels of body weight(BW)
fasting blood glucose(FBG)
blood urea nitrogen(BUN)
serum creatine(SCr)
albumin(ALB)
total cholesterol(TC)
triglyceride(TG)
24-hour urinary protein excretion(UPE)were detected.The kidney tissue was taken for histopathological observation and lesion grade.Result:QYJC decreased the levels of FBG
BUN
TC
TG
UAE significantly(P < 0.05 or 0.01)
it also reduced glomerulosclerosis index(P < 0.05 or 0.01) and tubu-lointerstitial fibrosis index(P < 0.05 or 0.01)as compared with DN model group.Conclusion: QYJC has a good re-nal protective effect in rats with diabetic nephropathy.The mechanism may be related to relieving blood lipid metabo-lism disorders.