Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice

YAN Hui1; SUN Xiao-di1; LIU Shou-cheng2; SUN Shi-guang1; ZHANG Wei-dong1; YANG Feng1; SHI Qi-rong1; XIE Yu-peng1; LIU Shuang3

doi:10.13422/j.cnki.syfjx.2011.04.053

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Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice

更新时间：2024-09-23

- Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 4, Pages: 157-159(2011)
- 作者机构：
  
  1. 北京军区总医院药剂科
  2. 中国人民解放军第二六六医院药剂科
  3. 北京军区司令部第二离职干部休养所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.04.053
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]闫荟,孙晓迪,刘守成,孙世光,张卫东,杨锋,史琪荣,谢予朋,刘爽.海金护卫散微粉对小鼠抗炎及镇痛作用[J].中国实验方剂学杂志,2011,17(04):157-159.

YAN Hui1, SUN Xiao-di1, LIU Shou-cheng2, et al. Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 157-159.
[1]闫荟,孙晓迪,刘守成,孙世光,张卫东,杨锋,史琪荣,谢予朋,刘爽.海金护卫散微粉对小鼠抗炎及镇痛作用[J].中国实验方剂学杂志,2011,17(04):157-159. DOI： 10.13422/j.cnki.syfjx.2011.04.053.

YAN Hui1, SUN Xiao-di1, LIU Shou-cheng2, et al. Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 157-159. DOI： 10.13422/j.cnki.syfjx.2011.04.053.

摘要

目的:考察海金护卫散微粉对小鼠的抗炎及镇痛效果。方法:实验小鼠分为6组:空白组

阿司匹林（1.4 g.kg-1）组

海金护卫散普通粉（1.5 g.kg-1）

海金护卫散微粉（4.5

3.0

1.5 g.kg-1）组

连续ig 7 d

采用二甲苯致小鼠耳廓肿胀法观察抗炎作用;采用热板法和扭体法观察对小鼠的镇痛作用。结果:海金护卫散微粉对二甲苯所致小鼠耳廓肿胀的抑制作用明显

呈现出随剂量增加而增强的趋势。与海金护卫散普通粉相当;与阿司匹林相当。海金护卫散微粉能使小鼠痛阈值提高

舔足次数减少;使小鼠扭体潜伏期延长

扭体次数减少。表明海金护卫散微粉具有明显的镇痛作用

与海金护卫散普通粉相当。结论:海金护卫散微粉对小鼠具有抗炎镇痛作用。

Abstract

Objective:To observe anti-inflammatory and analgesic activity in mice of Haijin Huwei San mi-cro-powder.Method: The model of xylene-induced auricular swelling in mice was used to observe the anti-inflam-matory effects.Analgesic effect of Haijin Huwei San micro-powder was investigated by hot plate test and acetic acid writhing test in mice.Result: Haijin Huwei San micro-powder could reduce the degree of tumefaction in auricle

with dose-dependent manner.Could reach the similar effect compared with Haijin Huwei San normal powder and as-pirin.The micro-powder Showed analgesia effect demostrated by hot plate method and stretching method

It’s analge-sic effect was the same to Haijin Huwei San normal powder.Conclusion: It indicates that Haijin Huwei San micro-powder has significant anti-inflammatory and analgesic effects in mice.

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Related Author

YAN Hui

SUN Xiao-di

LIU Shou-cheng

SUN Shi-guang

ZHANG Wei-dong

YANG Feng

SHI Qi-rong

XIE Yu-peng

Related Institution

The NATCM Third Grade Laboratory of TCM Preparations，Key Laboratory of Liver and Kidney Diseases （Ministry of Education）， Shanghai Key Laboratory of Traditional Chinese Clinical Medicine， Shuguang Hospital Affiliated to Shanghai University of TCM

Institute of Chinese Materia Medica， Shanghai University of TCM

College of Pharmaceutical Sciences， Zhejiang Chinese Medical University

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine （TCM）

Heilongjiang Ji Ren Pharmaceutical Co. Ltd.

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