SU Hong1, HUANG Chuan-sheng1, CHEN Wen1, et al. Intestinal Absorption of Shikonin in Rats by in Situ Single Pass Perfusion Method[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 190-192.
SU Hong1, HUANG Chuan-sheng1, CHEN Wen1, et al. Intestinal Absorption of Shikonin in Rats by in Situ Single Pass Perfusion Method[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 190-192. DOI: 10.13422/j.cnki.syfjx.2011.04.063.
Intestinal Absorption of Shikonin in Rats by in Situ Single Pass Perfusion Method
Objective:To study the in situ intestinal absorption behaviors of shikonin in rats.Method:The in situ rat single-pass intestinal perfusion model was used and the concentrations of the perfusate were determined by UV to investagate the intestinal absorption site and mechanism.Result:The Ka and Pappof shikonin showed colon > jejunum > duodenum > ileum in four different region of rat intestine.The Ka and Papp of every segment had no signifi-cant different from the others.The Ka and Papp of different drug concentration had no significant influence.Conclu-sion: Shikonin could be absorbed in whole intestinal segment
the best intestinal absorption site was colon.Its ab-sorbing mechanism may be related to passive diffusion.