Effect of Baicalin on Pharmacokinetics of Phillyrin in Rabbits

LI Zhao-xia1; NI Jian1; YIN Xing-bin1; HAN Lin-xin1

doi:10.13422/j.cnki.syfjx.2011.04.065

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Effect of Baicalin on Pharmacokinetics of Phillyrin in Rabbits

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- Effect of Baicalin on Pharmacokinetics of Phillyrin in Rabbits
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 4, Pages: 196-198(2011)
- 作者机构：
  
  1. 北京中医药大学中药学院
  2. 首都医科大学中医药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.04.065
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]李朝霞,倪健,尹兴斌,韩林辛.黄芩苷对连翘苷在家兔体内药动学的影响[J].中国实验方剂学杂志,2011,17(04):196-198.

LI Zhao-xia1, NI Jian1, YIN Xing-bin1, et al. Effect of Baicalin on Pharmacokinetics of Phillyrin in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 196-198.
[1]李朝霞,倪健,尹兴斌,韩林辛.黄芩苷对连翘苷在家兔体内药动学的影响[J].中国实验方剂学杂志,2011,17(04):196-198. DOI： 10.13422/j.cnki.syfjx.2011.04.065.

LI Zhao-xia1, NI Jian1, YIN Xing-bin1, et al. Effect of Baicalin on Pharmacokinetics of Phillyrin in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 196-198. DOI： 10.13422/j.cnki.syfjx.2011.04.065.

摘要

目的:探讨连翘苷及与黄芩苷配伍后静脉推注给药在家兔体内的药代动力学规律。方法:兔子10只

随机分为2组

Ⅰ组耳缘静脉推注连翘苷溶液1 mg.kg-1。Ⅱ组耳缘静脉推注连翘苷1 mg.kg-1和黄芩苷90 mg.kg-1

HPLC测定血浆中的连翘苷的药物浓度

kinetic软件求算其动力学参数

并进行统计学分析。结果:静脉给药后

连翘苷血药浓度的回归方程为Y=0.000 1X-2.933 6（r=0.997 3）

连翘苷在1.016～254 mg.L-1线性关系良好。非房室模型拟合后

单用和复合给药得到的连翘苷的主要药动学参数如药时曲线下面积AUC（0-∞）、平均滞留时间MRT（0-∞）、最大血药浓度Cmax、半衰期T1/2、超半峰浓度时间HVD等均有显著差异。结论:黄芩苷能够影响连翘苷在家兔体内的药动学过程。

Abstract

Objective:To investigate the pharmacokinetics of phillyrin and phillyrin-baicalin compound after intravenous injection（iv）in rabbits.Method: Ten rabbits were randomly divided into two groups.One group was administered with phillyrin（1 mg.kg-1） by iv

while the other were treated with phillyrin（1 mg.kg-1）-baicalin （90 mg.kg-1）compound by iv.The concentration of CA in plasma was determined by HPLC.The key parameters of pharmacokinetics were calculated and anylyzed by kinetic software.The calibration curve was linear（r = 0.997 3）in the range of 1.016-254 mg.L-1.Result: Concentration-time courses of phillyrin alone and phillyrin-baicalin compound were consistent with non-compartment model after iv.The key pharmacokinetic parameters of phillyrin alone were different with that of phillyrin-baicalin compound（P < 0.05）.Conclusion: Baicalin can affect the pharmacokinetics of constituent phillyrin in rabbits.

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YIN Xing-bin

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Related Institution

Soochow University

Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan province & Education Ministry of P.R. China

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Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory， Jiangxi Province Key Laboratory of TCM Etiopathogenisis， Jiangxi University of Chinese Medicine

Henan Academy of Chinese Medicine

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