Formulation Optimization and Drug Release Evaluation of pH-triggered Colon Specific Pellets of Sophora Flavescens

XIE Xing-liang1; YANG Ming2; HAN Li3; SHU Yi-jun1; CAI Cheng-ying1

doi:10.13422/j.cnki.syfjx.2011.04.079

您当前的位置：

首页 >

文章列表页 >

Formulation Optimization and Drug Release Evaluation of pH-triggered Colon Specific Pellets of Sophora Flavescens

更新时间：2024-09-23

- Formulation Optimization and Drug Release Evaluation of pH-triggered Colon Specific Pellets of Sophora Flavescens
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 4, Pages: 1-4(2011)
- 作者机构：
  
  1. 成都医学院药学院
  2. 江西中医学院现代中药制剂教育部重点实验室
  3. 成都中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.04.079
  CLC： R94
- Published：2011
- 稿件说明：
移动端阅览
[1]谢兴亮,杨明,韩丽,舒宜军,蔡成英.pH敏感型苦参结肠靶向微丸的处方筛选及其释药性能评价[J].中国实验方剂学杂志,2011,17(04):1-4.

XIE Xing-liang1, YANG Ming2, HAN Li3, et al. Formulation Optimization and Drug Release Evaluation of pH-triggered Colon Specific Pellets of Sophora Flavescens[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 1-4.
[1]谢兴亮,杨明,韩丽,舒宜军,蔡成英.pH敏感型苦参结肠靶向微丸的处方筛选及其释药性能评价[J].中国实验方剂学杂志,2011,17(04):1-4. DOI： 10.13422/j.cnki.syfjx.2011.04.079.

XIE Xing-liang1, YANG Ming2, HAN Li3, et al. Formulation Optimization and Drug Release Evaluation of pH-triggered Colon Specific Pellets of Sophora Flavescens[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 1-4. DOI： 10.13422/j.cnki.syfjx.2011.04.079.

摘要

目的:筛选确定pH敏感型苦参结肠靶向微丸的制剂处方

评价其释药性能。方法:采用挤出-滚圆法制备丸芯

以圆整度、脆碎度、得率、粒度分布、溶出度为评价指标

对丸芯处方进行筛选。采用流化床包衣技术

以释药性能为评价指标

对pH敏感包衣处方进行筛选

以浆法对包衣微丸的体外释药性能进行评价。结果:以主药4倍量的微晶纤维素为稀释剂

加入6%羧甲基淀粉钠混匀

加入28%水润湿

制软材

挤出滚圆得丸芯;以Eudragit S100为膜控材料

加入25%滑石粉

20%柠檬酸三乙酯

以95%乙醇为溶剂

配制包衣液

包衣使丸芯增重30%

得包衣微丸。该微丸在人工胃液、小肠液中苦参碱、氧化苦参碱的累积泄漏率为21.6%

结肠液中累积释放率达95.3%。结论:拟定了苦参结肠靶向微丸的制剂处方

制备得微丸质量稳定

具有良好结肠靶向释药性能。

Abstract

Objective:To optimize the prescription of pH-triggered colon specific pellets of Sophora flaves-cens to evaluate drug release.Method: The pellet core was prepared by extrusion-spheronization method

taking sphericity

friability

yield

particle size distribution and dissolution as index to optimize the prescription of the pellet core.The prescription of pH-triggered coat was optimized by fluidized bed coating technology with drug release as index.The drug release in vitro was evaluated with paddle method.Result:The pellet core was prepared by extrusion-spheronization method with 4 times principal agent cellulose microcrystalline as diluent

6% CMS-Na and 28% water added to prepare soft material.The coat solution was prepared with Eudragit S100 as film-forming agent

95% alcohol as solvent

25% talcum powder and 20% triethyl citrate added.The accumulation leakage ratio of matrine and oxymatrine from the coat pellets in gastric juice and small intestinal juice in vitro was 21.6%

and 95.3% in colon juice.Conclusion:The prescription of pH-triggered colon specific pellets of Sophora flavescens was made;the quality of pellets was stable and the drug release of colon target was satisfactory.

关键词

Keywords

references

Views

517

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Formulation Optimization and Drug Release Evaluation of pH-triggered Colon Specific Pellets of Sophora Flavescens

Evaluation of pH-triggered Double Layer Colon Target Pellets of

Research on Habitat Processes Method of

Study on Antimicrobial Activity of Alkaloids in and

Optimization of Extraction Technology of and from Fushubao Gel

Related Author

CAI Cheng-ying

SHU Yi-jun

HAN Li

YANG Ming

XIE Xing-liang

HU Wen-juan

LIU Jin-xiu

CHEN Cheng

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰