Effect of Compatibility of Chinese Thorowax Root and Lobed Kudzuvine Root on Body Temperature,Serum Content of IL-1β and Activity of MPO of Fever Rats

CHEN Cong; MA Cheng; XIAO Lu

doi:10.13422/j.cnki.syfjx.2011.05.017

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Effect of Compatibility of Chinese Thorowax Root and Lobed Kudzuvine Root on Body Temperature,Serum Content of IL-1β and Activity of MPO of Fever Rats

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- Effect of Compatibility of Chinese Thorowax Root and Lobed Kudzuvine Root on Body Temperature,Serum Content of IL-1β and Activity of MPO of Fever Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 207-209(2011)
- 作者机构：
  
  新疆医科大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.017
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]陈聪,马成,肖璐.柴胡葛根配伍对发热大鼠体温和血清IL-1β含量、MPO活性的影响[J].中国实验方剂学杂志,2011,17(05):207-209.

CHEN Cong, MA Cheng, XIAO Lu. Effect of Compatibility of Chinese Thorowax Root and Lobed Kudzuvine Root on Body Temperature,Serum Content of IL-1β and Activity of MPO of Fever Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 207-209.
[1]陈聪,马成,肖璐.柴胡葛根配伍对发热大鼠体温和血清IL-1β含量、MPO活性的影响[J].中国实验方剂学杂志,2011,17(05):207-209. DOI： 10.13422/j.cnki.syfjx.2011.05.017.

CHEN Cong, MA Cheng, XIAO Lu. Effect of Compatibility of Chinese Thorowax Root and Lobed Kudzuvine Root on Body Temperature,Serum Content of IL-1β and Activity of MPO of Fever Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 207-209. DOI： 10.13422/j.cnki.syfjx.2011.05.017.

摘要

目的:研究柴胡与葛根配伍在解热、抗炎等方面的作用。方法:56只雄性SD大鼠

随机分为空白组、模型组、阿司匹林组、柴胡组、葛根组、柴胡葛根3∶2组、柴胡葛根4∶5组共7组

每组8只

除空白组外

其余大鼠采用20%的干酵母悬液10 mL.kg-1大鼠背部皮下注射

建立发热模型。观察柴胡、葛根及其不同配伍比例的各组中药煎剂10 g.kg-1对发热大鼠的体温以及血清中炎性介质白介素-1β（IL-1β）含量、髓过氧化物酶（MPO）活性的影响。结果:柴胡、葛根及其不同配伍比例均具有降低发热大鼠体温和血清中IL-1β

MPO的作用

与模型组比（P<0.05或P<0.01）但配伍应用后作用明显优于单味柴胡或葛根。结论:柴胡与葛根配伍在解热、抗炎等方面具有显著的协同增效作用

发挥解热、抗炎的最佳配伍比例为柴胡葛根4∶5。

Abstract

Objective:To study the effect of Chinese thorowax root（CTR）and lobed kudzuvine root（LKR） compatible application on relieving fever rats and anti-inflammation.Method:the fever rat models are induced with back hypodermic injection of 20% dry yeast suspensions

observing the influence of CTR

LKR and their different com-patible proportions of decoction 10 g.kg-1 on body temperature of fever rats and the serum content of Interleukin-1β（IL-1β）and activity of myeloperoxidase（MPO）.Result:The different compatible proportions of CTR and LKR

CTR

and LKR can relieve fever

anti-inflammation compared to model group（P < 0.05 or P < 0.01）

but the effect of that compatible application obviously outstripped CTR or LKR only.Conclusion:The effect of CTR and LKR has signifi-cant synergistic effect on the aspects of relieving fever

anti-inflammation and so forth.The best compatible proportion of CTR and LKR on relieving fever

anti-inflammation is 4:5.

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Related Author

CHEN Cong

MA Cheng

XIAO Lu

CHEN Yaman

CUI Jinpeng

ZHANG Juan

LIU Qingpu

GONG Haiyan

Related Institution

College of Agronomy， Henan Agricultural University

Henan Provincial Engineering Technology Research Center for Quality Control and Evaluation of Traditional Chinese Medicine， Henan University of Chinese Medicine

Beijing University of Chinese Medicine

School of Traditional Chinese Medicine（TCM），Shanghai University of TCM

School of Chinese Materia Medica， Beijing University of Chinese Medicine

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