Experimental Study of Anti-alcoholism Effect of Yangyuan Decoction

XU Hui-qin; SHEN Cun-si; WU Cheng; CUI Jiao; LIU Bin

doi:10.13422/j.cnki.syfjx.2011.05.019

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Experimental Study of Anti-alcoholism Effect of Yangyuan Decoction

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- Experimental Study of Anti-alcoholism Effect of Yangyuan Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 213-215(2011)
- 作者机构：
  
  南京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.019
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]许惠琴,沈存思,吴诚,崔姣,刘斌.养元饮的解酒作用研究[J].中国实验方剂学杂志,2011,17(05):213-215.

XU Hui-qin, SHEN Cun-si, WU Cheng, et al. Experimental Study of Anti-alcoholism Effect of Yangyuan Decoction[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 213-215.
[1]许惠琴,沈存思,吴诚,崔姣,刘斌.养元饮的解酒作用研究[J].中国实验方剂学杂志,2011,17(05):213-215. DOI： 10.13422/j.cnki.syfjx.2011.05.019.

XU Hui-qin, SHEN Cun-si, WU Cheng, et al. Experimental Study of Anti-alcoholism Effect of Yangyuan Decoction[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 213-215. DOI： 10.13422/j.cnki.syfjx.2011.05.019.

摘要

目的:观察养元饮对醉酒小鼠以及醉酒大鼠的解酒作用。方法:通过单次ig食用酒建立醉酒小鼠及醉酒大鼠模型

并分别于ig食用酒前后ig给予养元饮。观察了养元饮对醉酒小鼠翻正反射消失以及恢复时间的影响

气相色谱法测醉酒大鼠体内血清中乙醇含量。结果:养元饮0.7

1.4 g.kg-1剂量组能明显缩短乙醇所致小鼠的睡眠时间;养元饮0.35

0.7 g.kg-1剂量组明显降低醉酒大鼠血清中乙醇含量

作用优于海王金樽。结论:提示养元饮通过缓解消化道损伤

加快乙醇在体内代谢从而达到解酒作用。

Abstract

Objective:To observe anti-alcoholism effect of Yangyuan Decoction on drunken mice and rats.Method:The drunken model of mouse and rat was established through a single ig wine drink.Effects of Yangyuan Decoction（ig）were tested for prevention and treatment.The influence of Yangyuan Decoction on the disappearance of righting reflex and recovery time for drunken mice was observed.We employed gas chromatography to detect alco-hol concentration in rat serum.Result:The dose of 0.7

1.4 g.kg-1group of Yangyuan Decoction could significantly reduce the ethanol-induced sleep time in mice;the 0.35

0.7 g.kg-1dose group of Yangyuan Decoction could signif-icantly reduce alcohol concentration in rat serum.The effect was better than Neptune Jinzun.Conclusion:Anti-alco-holism effect of Yangyuan Decoction is likely achieved through mitigating gastrointestinal damage and speeding up alcohol metabolism in vivo.

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