Effect of Buqi Xiaopi Decoction on Experimental Chronic Fatigue Syndrome

LIU Xiu-feng; LIANG Mao-xin; ZHANG Hong

doi:10.13422/j.cnki.syfjx.2011.05.020

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Effect of Buqi Xiaopi Decoction on Experimental Chronic Fatigue Syndrome

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- Effect of Buqi Xiaopi Decoction on Experimental Chronic Fatigue Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 219-222(2011)
- 作者机构：
  
  辽宁中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.020
  CLC： R285.5
- Published：2011
- 稿件说明：
移动端阅览
[1]刘秀峰,梁茂新,张宏.补气消疲饮对实验性慢性疲劳综合征的影响[J].中国实验方剂学杂志,2011,17(05):219-222.

LIU Xiu-feng, LIANG Mao-xin, ZHANG Hong. Effect of Buqi Xiaopi Decoction on Experimental Chronic Fatigue Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 219-222.
[1]刘秀峰,梁茂新,张宏.补气消疲饮对实验性慢性疲劳综合征的影响[J].中国实验方剂学杂志,2011,17(05):219-222. DOI： 10.13422/j.cnki.syfjx.2011.05.020.

LIU Xiu-feng, LIANG Mao-xin, ZHANG Hong. Effect of Buqi Xiaopi Decoction on Experimental Chronic Fatigue Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 219-222. DOI： 10.13422/j.cnki.syfjx.2011.05.020.

摘要

目的:观察补气消疲饮对实验性慢性疲劳综合征的影响。方法:实验分3组进行:第1组选用18～22 g ICR小鼠70只

SPF级

雌雄各半

每组10只

按体重随机分为7组

即空白对照组

模型对照组

补气消疲饮低、中、高（按生药量计6.5

26 g.kg-1.d-1）剂量组。生力胶囊（0.546 g.kg-1.d-1）组

复方氨基酸胶囊（0.273 g.kg-1.d-1）组

每天ig给药1次

连续7 d

测量并记录小鼠负重游泳时间、出离水迷宫时间以及脾脏质量;第2

3组实验动物、用药剂量、给药途径以及给药天数同第1组

复方氨基酸胶囊组改为醋酸地塞米松片（0.39 mg.kg-1.d-1）组

测定小鼠迟发超敏反应和血清溶血素含量的变化。结果:模型组

补气消疲饮低、中、高剂量组小鼠游泳时间分别为（1045±155）s

（1561±242）

（1958±605）

（2394±414）s

与模型组比较明显延长（P<0.01）;出离水迷宫时间分别为（57±12）

（46±12）

（42±13）

（33±7）s

同模型组比较明显缩短（P<0.01）;脾脏质量差异不显著;耳片质量之差分别为（1.85±0.55）

（1.54±0.57）

（1.29±0.71）

（0.84±0.46）g

A分别为0.593±0.315

0.701±0.360

0.829±0.166

0.929±0.290

同模型组比较耳片质量之差减小（P<0.01）

A值增大（P<0.01）。结论:补气消疲饮能够延长小鼠负重游泳时间、减少出离水迷宫时间

抑制2

4-二硝基氯苯所致迟发超敏反应、促进血清溶血素生成

具有抗疲劳、增强学习记忆能力和提高机体免疫力的作用。

Abstract

Objective:To observe the effect of Buqi Xiaopi decoction on experimental chronic fatigue syn-drome（CFS）.Method:weight loading swimming time

passing morris water maze time

weight of spleen

delayed hypersensitive reaction（DHR）and serum hemolysin contents were selected to observe the effect of Buqi Xiaopi de-coction in mouse.Result:Buqi Xiaopi decoction could prolong the weight loading swimming time

reduce the passing morris water maze time

increase the weight of spleen

inhibit the DHR due to 2

4-dinitrochlorobenzene

and prove the serum hemolysin contents.Conclusion:Buqi Xiaopi decoction has the effect of antifatigue

improving learning and remembrance ability

immunity

so that it can be an effective traditional Chinese medicine prescription for CFS.The study establishes the foundation for clinical application and further researches.

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Related Author

LIU Xiu-feng

LIANG Mao-xin

Zhang Hong

TIAN Yuefeng

ZHAI Chuntao

HOU Yawei

SHI Linjuan

WANG Yixiao

Related Institution

Second Clinical College of Shanxi University of Chinese Medicine

Jiange Hospital of TCM

Pengzhou People's Hospital，Pengzhou

Chengdu University of TCM

Sichuan Institute for Translational Chinese Medicine（TCM）

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