Protective Effect of Total Flavone of Engelhardtia roxburghiana Folium on Experimental Cerebral Ischemia in Rats

PAN Zhao-bin; LI Fei-chao; LIAO Yue-e; LIN Xiao-song

doi:10.13422/j.cnki.syfjx.2011.05.021

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Protective Effect of Total Flavone of Engelhardtia roxburghiana Folium on Experimental Cerebral Ischemia in Rats

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- Protective Effect of Total Flavone of Engelhardtia roxburghiana Folium on Experimental Cerebral Ischemia in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 223-226(2011)
- 作者机构：
  
  广西贵港市第二人民医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.021
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]潘照斌,李棐朝,廖月娥,林晓崧.黄杞叶总黄酮对大鼠实验性脑缺血保护作用的研究[J].中国实验方剂学杂志,2011,17(05):223-226.

PAN Zhao-bin, LI Fei-chao, LIAO Yue-e, et al. Protective Effect of Total Flavone of Engelhardtia roxburghiana Folium on Experimental Cerebral Ischemia in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 223-226.
[1]潘照斌,李棐朝,廖月娥,林晓崧.黄杞叶总黄酮对大鼠实验性脑缺血保护作用的研究[J].中国实验方剂学杂志,2011,17(05):223-226. DOI： 10.13422/j.cnki.syfjx.2011.05.021.

PAN Zhao-bin, LI Fei-chao, LIAO Yue-e, et al. Protective Effect of Total Flavone of Engelhardtia roxburghiana Folium on Experimental Cerebral Ischemia in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 223-226. DOI： 10.13422/j.cnki.syfjx.2011.05.021.

摘要

目的:研究黄杞总黄酮对大鼠实验性脑缺血的保护作用。方法:取Wistar大鼠

随机分为假手术组、模型组、黄杞总黄酮组（500

250

125 mg.kg-1）和三七通舒胶囊（50 mg.kg-1）组

采用线栓法和结扎双侧颈总动脉法复制大鼠脑缺血模型

观察黄杞总黄酮对局灶性脑缺血大鼠神经功能症状、脑梗死面积

对急性脑缺血再灌注损伤大鼠脑含水量以及脑组织SOD活性、MDA和NO水平的影响。结果:黄杞总黄酮对局灶性脑缺血大鼠的神经运动障碍有明显改善作用

也明显减小脑梗死面积;同时能减轻急性脑缺血再灌注损伤引起的大鼠脑水肿

提高损伤脑组织的SOD活性

降低MAO以及NO水平。结论:黄杞总黄酮对大鼠实验性脑缺血有一定的保护作用。

Abstract

Objective:To explore the protective effect of total flavone of Engelhardtia roxburghiana（TFER） on experimental cerebral ischemia of rats.Method:Sixty Wistar rats were randomized into pseudo operation group

model group

TFER groups（500

250

125 mg.kg-1）

Sanqi Tongshu Capsule group（50 mg.kg-1）.Methods of oc-clusion of middle cerebral artery and occlusion of bilateral common carotid arteries with ligation were used to estab-lish rat models of cerebral ischemia

and the effect of symptom of neurological function and area of cerebral infarc-tion were measured for focal cerebral ischemia injury model

and cerebral water content

the SOD activity

MDA and NO level were determined for acute cerebral ischemia-reperfusion injury model.Result:TFER could improve neuro-logical function and decrease the area of ischemia

and palliate cerebral edema

increase the SOD activity

and de-crease the MDA and NO level in the brain tissue in the rats.Conclusion:TFER has a protective effect on experimen-tal cerebral ischemia of rats.

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Related Author

LIN Xiao-song

LIAO Yue-e

LI Fei-chao

PAN Zhao-bin

ZHANG Yunke

LIU Feixiang

GAO Jing

YAO Mingjiang

Related Institution

Henan University of Chinese Medicine

The First Affiliated Hospital of Henan University of Chinese Medicine

Beijing Key Laboratory of Pharmacology of Chinese Materia Medica，Institute of Basic Medical Sciences of Xiyuan Hospital，China Academy of Chinese Medical Sciences

Xi'an Buchang Traditional Chinese Cardio-Cerebrovascular Disease Hospital

Shandong University of Traditional Chinese Medicine(TCM)

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