CHEN Yan-jun1, JIA Yan1, JIN Ri-xian1, et al. Preparation of Baicalin Flexible nano-Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 1-4.
CHEN Yan-jun1, JIA Yan1, JIN Ri-xian1, et al. Preparation of Baicalin Flexible nano-Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 1-4. DOI: 10.13422/j.cnki.syfjx.2011.05.032.
Preparation of Baicalin Flexible nano-Liposomes
摘要
目的:制备黄芩苷柔性纳米脂质体。方法:采用薄膜分散法制备柔性纳米脂质体混悬液
以黄芩苷的含量作为工艺研究中包封率的评价指标
以粒径、粒径分散系数
Zeta电位及包封率为考察指标
采用正交试验筛选最佳处方和制备工艺条件
并考察其物理化学性质。结果:最佳处方和制备工艺条件为卵磷脂与胆酸钠的质量比6∶1
卵磷脂与黄芩苷的质量比10∶1
探头超声时间15 min。包封率60.11%
所得的柔性纳米脂质体为类球形实体粒子
平均粒径175 nm
平均Zeta电位-78.9 mV。结论:黄芩苷柔性纳米脂质体处方和制备工艺基本可行。
Abstract
Objective:To prepare baicalin flexible nano-liposomes.Method:By film dispersion method to prepare flexible nano liposome suspension to the content of baicalin in encapsulation efficiency as the technology of the evaluation index
particle size
particle size dispersion coefficient
Zeta potential and entrapment efficiency of the indexes
the best prescription by orthogonal test and the preparation conditions
and studied its physical and chemical properties.Result:The best prescription and conditions for the preparation of lecithin and sodium cholate mass ratio of 6 :1
lecithin and baicalin is a 10 :1 ratio
ultrasonic probe time is 15min.The encapsulation efficiency was 60.11%
from the flexible nano-liposomes are spherical solid particles
average particle size of 175 nm
the average Zeta potential was-78.9 mV.Conclusion:Baicalin flexible nano-liposomes formulation and preparation process are basically feasible.
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Related Author
CHEN Yan-jun
JIA Yan
JIN Ri-xian
XU Jia-yin
XIONG-xin
YUAN Jun-lin
LIU Shu-zhi
CHEN Mengjie
Related Institution
Research Center for Differentiation and Development of Traditional Chinese Medicine (TCM) Basic Theory, Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Jiangxi University of Chinese Medicine
Henan Academy of Chinese Medicine
The Second Clinical Medical College, Henan University of Chinese Medicine
State Key Laboratory of Functions and Applications of Medicinal Plants,School of Pharmaceutical Sciences,Engineering Center of Microbiology and Biochemical Pharmacy,Experimental Animal Center,Guizhou Medical University
Chengdu University of Traditional Chinese Medicine