Changes of Content of Main Components in Coptis and Magnolia with Different Extractions

WU An-guo1; ZENG Bao1; LIN Qiao1; HE Bai-yin1; CHEN Jian-nan1; LAI Xiao-ping1

doi:10.13422/j.cnki.syfjx.2011.05.036

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Changes of Content of Main Components in Coptis and Magnolia with Different Extractions

更新时间：2024-09-23

- Changes of Content of Main Components in Coptis and Magnolia with Different Extractions
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 19-22(2011)
- 作者机构：
  
  1. 广州中医药大学新药开发研究中心
  2. 东莞广州中医药大学中医药数理工程研究院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.036
  CLC： R284.1
- Published：2011
- 稿件说明：
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[1]吴安国,曾宝,林乔,何百寅,陈建南,赖小平.黄连厚朴配伍在不同提取工艺中主要成分含量的变化[J].中国实验方剂学杂志,2011,17(05):19-22.

WU An-guo1, ZENG Bao1, LIN Qiao1, et al. Changes of Content of Main Components in Coptis and Magnolia with Different Extractions[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 19-22.
[1]吴安国,曾宝,林乔,何百寅,陈建南,赖小平.黄连厚朴配伍在不同提取工艺中主要成分含量的变化[J].中国实验方剂学杂志,2011,17(05):19-22. DOI： 10.13422/j.cnki.syfjx.2011.05.036.

WU An-guo1, ZENG Bao1, LIN Qiao1, et al. Changes of Content of Main Components in Coptis and Magnolia with Different Extractions[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 19-22. DOI： 10.13422/j.cnki.syfjx.2011.05.036.

摘要

目的:比较黄连厚朴不同提取工艺

不同配伍比例主要成分含量的变化。方法:1.黄连厚朴以水和乙醇2种溶剂

采用分提与合提2种提取方法;2.以乙醇为溶剂

黄连厚朴以3∶1

2∶1

1∶1

1∶2

1∶3不同配伍比例提取

采用高效液相色谱法

测定小檗碱、厚朴酚、和厚朴酚的含量。结果:①黄连厚朴的乙醇提取工艺的提取率优于水提取

而在水合提工艺中小檗碱的含量下降40%

在醇提工艺中只下降1%

厚朴的含量在合提工艺中均比分提提高了2%左右。②当配伍比例为1:1的时候小檗碱的提取率较高

厚朴比例越低

其提取率越高。结论:黄连厚朴应采取醇合提的工艺

在提取工艺中

应考虑中药化学成分的不同理化性质

采取适宜的提取溶剂和提取方法。

Abstract

Objective:To compare the different extraction techniques for Coptis and Magnolia and the changes of the main components in extracting Coptis and Magnolia with different proportion.Method:Coptis and Magnolia were extracted together or alone by using two kinds of solvents including water and alcohol with different propor-tions as 3:1

2:1

1:1

1:2 and 1:3 to determine the content of berberine

magnolol and honokiol by HPLC.Result:The extraction rate of Coptis and Magnolia with alcohol was better than that with water.The content of berberine was decreased 40% as extracting together by water

but was decreased only 1% as extracting together by alcohol.The content of magnolol and honokiol was increased 2% as extracting together with alcohol or water.The extraction rate of berberine was high when the ratio was 1:1.The higher of the extraction rate

the lower of the content of magnolol and honokiol would be.Conclusion:Coptis and Magnolia should be extracted together by alcohol.In the extraction process

in order to take the appropriate solvent and extraction methods

the chemical constituents of traditional Chinese medicine should be considered in different physical and chemical properties.

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Related Author

WU An-guo

ZENG Bao

LIN Qiao

HE Bai-yin

CHEN Jian-nan

LAI Xiao-ping

LAN Qun

CHENG Yi

Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Medical School， Lijiang Culture and Tourism College

Chengdu University of TCM

Key Laboratory of Modern Preparation of Traditional Chinese Medicine （TCM），Ministry of Education，Jiangxi University of Chinese Medicine

Jiangsu Rongyu Pharmaceutical Co. Ltd.

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